Purpose. The Lofoten Basin is one of the most energetic zones of the World Ocean characterized by high activity of mesoscale eddies. The study is aimed at analyzing different components of general energy in the basin, namely the mean kinetic and vortex kinetic energy calculated using the integral of the volume of available potential and kinetic energy of the Lofoten Vortex, as well as variability of these characteristics. Methods and Results. GLORYS12V1 reanalysis data for the period 2010–2018 were used. The mean kinetic energy and the eddy kinetic one were analyzed; and as for the Lofoten Vortex, its volume available potential and kinetic energy was studied. Mesoscale activity of eddies in winter is higher than in summer. Evolution of the available potential energy and kinetic energy of the Lofoten Vortex up to the 1000 m horizon was studied. It is shown that the vortex available potential energy exceeds the kinetic one by an order of magnitude, and there is a positive trend with the coefficient 0,23⋅10¹⁵ J/year. It was found that in the Lofoten Basin, the intermediate layer from 600 to 900 m made the largest contribution to the potential energy, whereas the 0–400 m layer – to kinetic energy. The conversion rates of the mean kinetic energy into the vortex kinetic one, and the mean available potential energy into the vortex available potential one (baroclinic and barotropic instability) were analyzed. It is shown that the first type of transformation dominates in summer, while the second one is characterized by its increase in winter. Conclusions. The vertical profile shows that kinetic energy of eddies in winter is higher than in summer. The available potential energy of a vortex is by an order of magnitude greater than the kinetic energy. Increase in the available potential energy is confirmed by a significant positive trend and by decrease of the vortex Burger number. The graphs of the barotropic instability conversion rate demonstrate the multidirectional flows in the vortex zone with the dipole structure observed in a winter period, and the tripole one – in summer. The barotropic instability highest intensity is observed in summer. The baroclinic instability is characterized by intensification of the regime in winter that is associated with weakening of stratification in this period owing to winter convection.