The article is devoted to an empirical research of the personal qualities influence on the professional health of sales managers. Due to the modeling performed with the structural equations the authors defined that the influence is of a hierarchical structure and found two major determining factors. The personal maturity factor explicates 63% of dispersion; the indicators of this factor are socialization, self-control, tolerance, achievement through independence, existential values. The self-actualization factor explicates 26% of dispersion, the factor indicators being intellectual efficiency, synergy, sociability, cognition, selfacceptance. The researchers also defined the influence of exogenous factors of gender and nationality and the negative impact of premorbid rigidity and motivation of avoiding failures on the professional health. The research was conducted in Russia in the Republic of Khakassia in 2017.