TY - JOUR

T1 - STATISTICAL MODELS SUGGEST PRESENCE OF TWO DISTINCT SUBPOPULATIONS OF MINIATURE EPSCs IN FAST-SPIKING INTERNEURONS OF RAT PREFRONTAL CORTEX

AU - Malkin, S.L.

AU - Kim, K.K.

AU - Tikhonov, D.B.

AU - Magazanik, L.G.

AU - Zaitsev, A.V.

PY - 2015

Y1 - 2015

N2 - Properties of excitatory synaptic responses in fast-spiking interneurons (FSIs) and pyramidal neurons (PNs) are different; however, the mechanisms and determinants of this diversity have not been fully investigated. In the present study, voltage-clamp recording of miniature excitatory post-synaptic currents (mEPSCs) was performed of layer 2-3 FSIs and PNs in the medial prefrontal cortex of rats aged 19-22 days. The average mEPSCs in the FSIs exhibited amplitudes that were two times larger than those of the PNs and with much faster rise and decay. The mEPSC amplitude distributions in both cell types were asymmetric and in FSIs, the distributions were more skewed and had two-times larger coefficients of variation than in the PNs. In PNs but not in FSIs, the amplitude distributions were fitted well by different skewed unimodal functions that have been used previously for this purpose. In the FSIs, the distributions were well approximated only by a sum of two such functions, suggesting the presence of at least tw

AB - Properties of excitatory synaptic responses in fast-spiking interneurons (FSIs) and pyramidal neurons (PNs) are different; however, the mechanisms and determinants of this diversity have not been fully investigated. In the present study, voltage-clamp recording of miniature excitatory post-synaptic currents (mEPSCs) was performed of layer 2-3 FSIs and PNs in the medial prefrontal cortex of rats aged 19-22 days. The average mEPSCs in the FSIs exhibited amplitudes that were two times larger than those of the PNs and with much faster rise and decay. The mEPSC amplitude distributions in both cell types were asymmetric and in FSIs, the distributions were more skewed and had two-times larger coefficients of variation than in the PNs. In PNs but not in FSIs, the amplitude distributions were fitted well by different skewed unimodal functions that have been used previously for this purpose. In the FSIs, the distributions were well approximated only by a sum of two such functions, suggesting the presence of at least tw

U2 - 10.1016/j.neuroscience.2015.06.034

DO - 10.1016/j.neuroscience.2015.06.034

M3 - Article

VL - 301

SP - 508

EP - 519

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -