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Statistical design for a small serial dilution series. / Zelterman, Daniel; Tulupyev, Alexander; Heimer, Robert; Abdala, Nadia.

в: Statistics in Medicine, Том 29, № 3, 2010, стр. 411--420.

Результаты исследований: Научные публикации в периодических изданиях › статья

Harvard

Zelterman, D, Tulupyev, A, Heimer, R & Abdala, N 2010, 'Statistical design for a small serial dilution series', Statistics in Medicine, Том. 29, № 3, стр. 411--420. https://doi.org/10.1002/sim.3774

APA

Zelterman, D., Tulupyev, A., Heimer, R., & Abdala, N. (2010). Statistical design for a small serial dilution series. Statistics in Medicine, 29(3), 411--420. https://doi.org/10.1002/sim.3774

Vancouver

Zelterman D, Tulupyev A, Heimer R, Abdala N. Statistical design for a small serial dilution series. Statistics in Medicine. 2010;29(3):411--420. https://doi.org/10.1002/sim.3774

Author

Zelterman, Daniel ; Tulupyev, Alexander ; Heimer, Robert ; Abdala, Nadia. / Statistical design for a small serial dilution series. в: Statistics in Medicine. 2010 ; Том 29, № 3. стр. 411--420.

BibTeX

@article{27fc5944cee244c1a2ef19998b57d060,
title = "Statistical design for a small serial dilution series",
abstract = "We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of human immunodeficiency virus in syringes and other equipment that might mediate blood-borne viral transmission.",
keywords = "binomial distribution, entropy, experimental design, harm reduction, hiv infection, syringe exchange",
author = "Daniel Zelterman and Alexander Tulupyev and Robert Heimer and Nadia Abdala",
year = "2010",
doi = "10.1002/sim.3774",
language = "English",
volume = "29",
pages = "411----420",
journal = "Statistics in Medicine",
issn = "0277-6715",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Statistical design for a small serial dilution series

AU - Zelterman, Daniel

AU - Tulupyev, Alexander

AU - Heimer, Robert

AU - Abdala, Nadia

PY - 2010

Y1 - 2010

N2 - We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of human immunodeficiency virus in syringes and other equipment that might mediate blood-borne viral transmission.

AB - We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of human immunodeficiency virus in syringes and other equipment that might mediate blood-borne viral transmission.

KW - binomial distribution

KW - entropy

KW - experimental design

KW - harm reduction

KW - hiv infection

KW - syringe exchange

U2 - 10.1002/sim.3774

DO - 10.1002/sim.3774

M3 - Article

VL - 29

SP - 411

EP - 420

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 3

ER -

ID: 5288517