The lifetime of antiskyrmions at room temperature in an Mn–Pt–Sn tetragonal Heusler material has been calculated using an atomic scale representation including nearly a million spins. The evaluation of the pre-exponential factor in the Arrhenius rate expression for this large system is made possible by implementation of harmonic transition state theory that avoids evaluation of the eigenvalues of the Hessian matrix. The parameter values in the extended Heisenberg Hamiltonian, including anisotropic Dzyaloshinskii-Moriya interaction, are chosen to reproduce experimental observations [Nayak et al., Nature (London) 548, 561 (2017)], in particular, the 150-nm diameter. The calculated results are consistent with the long lifetime observed in the laboratory and this exceptional stability of the antiskyrmions is found to result from large activation energy for collapse due to strong exchange coupling while the pre-exponential factor in the Arrhenius expression for the lifetime is found to have a typical magnitude of 10−12 s, despite the large number of spins. The long lifetime is, therefore, found to result from energetic effects rather than entropic effects in this system.