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Spatiotemporal structure of cell fate decisions in murine neural crest. / Soldatov, Ruslan; Kaucka, Marketa; Kastriti, Maria Eleni; Petersen, Julian; Chontorotzea, Tatiana; Englmaier, Lukas; Akkuratova, Natalia; Yang, Yunshi; Häring, Martin; Dyachuk, Viacheslav; Bock, Christoph; Farlik, Matthias; Piacentino, Michael L.; Boismoreau, Franck; Hilscher, Markus M.; Yokota, Chika; Qian, Xiaoyan; Nilsson, Mats; Bronner, Marianne E.; Croci, Laura; Hsiao, Wen Yu; Guertin, David A.; Brunet, Jean Francois; Consalez, Gian Giacomo; Ernfors, Patrik; Fried, Kaj; Kharchenko, Peter V.; Adameyko, Igor.

в: Science, Том 364, № 6444, aas9536, 07.06.2019.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Soldatov, R, Kaucka, M, Kastriti, ME, Petersen, J, Chontorotzea, T, Englmaier, L, Akkuratova, N, Yang, Y, Häring, M, Dyachuk, V, Bock, C, Farlik, M, Piacentino, ML, Boismoreau, F, Hilscher, MM, Yokota, C, Qian, X, Nilsson, M, Bronner, ME, Croci, L, Hsiao, WY, Guertin, DA, Brunet, JF, Consalez, GG, Ernfors, P, Fried, K, Kharchenko, PV & Adameyko, I 2019, 'Spatiotemporal structure of cell fate decisions in murine neural crest', Science, Том. 364, № 6444, aas9536. https://doi.org/10.1126/science.aas9536

APA

Soldatov, R., Kaucka, M., Kastriti, M. E., Petersen, J., Chontorotzea, T., Englmaier, L., Akkuratova, N., Yang, Y., Häring, M., Dyachuk, V., Bock, C., Farlik, M., Piacentino, M. L., Boismoreau, F., Hilscher, M. M., Yokota, C., Qian, X., Nilsson, M., Bronner, M. E., ... Adameyko, I. (2019). Spatiotemporal structure of cell fate decisions in murine neural crest. Science, 364(6444), [aas9536]. https://doi.org/10.1126/science.aas9536

Vancouver

Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L и пр. Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019 Июнь 7;364(6444). aas9536. https://doi.org/10.1126/science.aas9536

Author

Soldatov, Ruslan ; Kaucka, Marketa ; Kastriti, Maria Eleni ; Petersen, Julian ; Chontorotzea, Tatiana ; Englmaier, Lukas ; Akkuratova, Natalia ; Yang, Yunshi ; Häring, Martin ; Dyachuk, Viacheslav ; Bock, Christoph ; Farlik, Matthias ; Piacentino, Michael L. ; Boismoreau, Franck ; Hilscher, Markus M. ; Yokota, Chika ; Qian, Xiaoyan ; Nilsson, Mats ; Bronner, Marianne E. ; Croci, Laura ; Hsiao, Wen Yu ; Guertin, David A. ; Brunet, Jean Francois ; Consalez, Gian Giacomo ; Ernfors, Patrik ; Fried, Kaj ; Kharchenko, Peter V. ; Adameyko, Igor. / Spatiotemporal structure of cell fate decisions in murine neural crest. в: Science. 2019 ; Том 364, № 6444.

BibTeX

@article{8a4503fd247d4c73aea64278e14dc83e,
title = "Spatiotemporal structure of cell fate decisions in murine neural crest",
abstract = "Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.",
author = "Ruslan Soldatov and Marketa Kaucka and Kastriti, {Maria Eleni} and Julian Petersen and Tatiana Chontorotzea and Lukas Englmaier and Natalia Akkuratova and Yunshi Yang and Martin H{\"a}ring and Viacheslav Dyachuk and Christoph Bock and Matthias Farlik and Piacentino, {Michael L.} and Franck Boismoreau and Hilscher, {Markus M.} and Chika Yokota and Xiaoyan Qian and Mats Nilsson and Bronner, {Marianne E.} and Laura Croci and Hsiao, {Wen Yu} and Guertin, {David A.} and Brunet, {Jean Francois} and Consalez, {Gian Giacomo} and Patrik Ernfors and Kaj Fried and Kharchenko, {Peter V.} and Igor Adameyko",
year = "2019",
month = jun,
day = "7",
doi = "10.1126/science.aas9536",
language = "English",
volume = "364",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6444",

}

RIS

TY - JOUR

T1 - Spatiotemporal structure of cell fate decisions in murine neural crest

AU - Soldatov, Ruslan

AU - Kaucka, Marketa

AU - Kastriti, Maria Eleni

AU - Petersen, Julian

AU - Chontorotzea, Tatiana

AU - Englmaier, Lukas

AU - Akkuratova, Natalia

AU - Yang, Yunshi

AU - Häring, Martin

AU - Dyachuk, Viacheslav

AU - Bock, Christoph

AU - Farlik, Matthias

AU - Piacentino, Michael L.

AU - Boismoreau, Franck

AU - Hilscher, Markus M.

AU - Yokota, Chika

AU - Qian, Xiaoyan

AU - Nilsson, Mats

AU - Bronner, Marianne E.

AU - Croci, Laura

AU - Hsiao, Wen Yu

AU - Guertin, David A.

AU - Brunet, Jean Francois

AU - Consalez, Gian Giacomo

AU - Ernfors, Patrik

AU - Fried, Kaj

AU - Kharchenko, Peter V.

AU - Adameyko, Igor

PY - 2019/6/7

Y1 - 2019/6/7

N2 - Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.

AB - Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.

UR - http://www.scopus.com/inward/record.url?scp=85067422625&partnerID=8YFLogxK

U2 - 10.1126/science.aas9536

DO - 10.1126/science.aas9536

M3 - Article

C2 - 31171666

AN - SCOPUS:85067422625

VL - 364

JO - Science

JF - Science

SN - 0036-8075

IS - 6444

M1 - aas9536

ER -

ID: 61016983