Supersymmetrical (SUSY) intertwining relations are generalized to the case of quantum Hamiltonians in Minkowski space. For intertwining operators (supercharges) of second order in derivatives the intertwined Hamiltonians correspond to completely integrable systems with the symmetry operators of fourth order in momenta. In terms of components, the itertwining relations correspond to the system of nonlinear differential equations which are solvable with the simplest - constant - ansatzes for the "metric" matrix in second order part of the supercharges. The corresponding potentials are built explicitly both for diagonalizable and nondiagonalizable form of "metric" matrices, and their properties are discussed.