TY - JOUR

T1 - Smart photopharmacological agents: LaVO4:Eu3+@Vinyl Phosphonate combining luminescence imaging and photoswitchable butyrylcholinesterase inhibition

AU - Бикбаева, Гулия Ильнуровна

AU - Пилип, Анна Георгиевна

AU - Егорова, Анастасия Валерьевна

AU - Медведев, Василий Андреевич

AU - Мамонова, Дарья Владимировна

AU - Панькин, Дмитрий Васильевич

AU - Калиничев, Алексей Андреевич

AU - Mayachkina, Natalia

AU - Бакина, Людмила Георгиевна

AU - Колесников, Илья Евгеньевич

AU - Leuchs, Gerd

AU - Маньшина, Алина Анвяровна

PY - 2024/8/20

Y1 - 2024/8/20

N2 - The combination of photoswitchability and bioactivity in one compound provides interesting opportunities for photopharmacology. Here, we report a hybrid compound that in addition allows for its visual localization. It is the first demonstration of its kind and it even shows high photoswitchability. The multifunctional nanomaterial hybrid, which we present, is composed of luminescent LaVO4:Eu3+ nanoparticles and vinyl phosphonate, the latter of which inhibits butyrylcholinesterase (BChE). This inhibition increases 7 times when irradiated with a 266 nm laser. We found that it is increased even further when vinyl phosphonate molecules are conjugated with LaVO4:Eu3+ nanoparticles, leading in total to a 20-fold increase in BChE inhibition upon laser irradiation. The specific luminescence spectrum of LaVO4:Eu3+ allows its spatial localization in various biological samples (chicken breast, Daphnia and Paramecium). Furthermore, laser irradiation of the LaVO4:Eu3+@vinyl phosphonate hybrid leads to a drop in luminescence intensity and in lifetime of the Eu3+ ion that can implicitly indicate photoswitching of vinyl phosphonate in the bioactive state. Thus, combining enhanced photoswitchability, bioactivity and luminescence induced localizability in a unique way, hybrid LaVO4:Eu3+@vinyl phosphonate can be considered as a promising tool for photopharmacology.

AB - The combination of photoswitchability and bioactivity in one compound provides interesting opportunities for photopharmacology. Here, we report a hybrid compound that in addition allows for its visual localization. It is the first demonstration of its kind and it even shows high photoswitchability. The multifunctional nanomaterial hybrid, which we present, is composed of luminescent LaVO4:Eu3+ nanoparticles and vinyl phosphonate, the latter of which inhibits butyrylcholinesterase (BChE). This inhibition increases 7 times when irradiated with a 266 nm laser. We found that it is increased even further when vinyl phosphonate molecules are conjugated with LaVO4:Eu3+ nanoparticles, leading in total to a 20-fold increase in BChE inhibition upon laser irradiation. The specific luminescence spectrum of LaVO4:Eu3+ allows its spatial localization in various biological samples (chicken breast, Daphnia and Paramecium). Furthermore, laser irradiation of the LaVO4:Eu3+@vinyl phosphonate hybrid leads to a drop in luminescence intensity and in lifetime of the Eu3+ ion that can implicitly indicate photoswitching of vinyl phosphonate in the bioactive state. Thus, combining enhanced photoswitchability, bioactivity and luminescence induced localizability in a unique way, hybrid LaVO4:Eu3+@vinyl phosphonate can be considered as a promising tool for photopharmacology.

UR - https://www.mendeley.com/catalogue/c17c9f71-7d26-314b-839f-2eceff998cee/

U2 - 10.1039/D4NA00389F

DO - 10.1039/D4NA00389F

M3 - Article

C2 - 39170980

VL - 6

SP - 4417

EP - 4425

JO - Nanoscale Advances

JF - Nanoscale Advances

SN - 2516-0230

IS - 17

M1 - 4417

ER -