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Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin. / Kameneva, P.; Artemov, A.V.; Kastriti, Maria Eleni ; Faure, L.; Olsen, T.K.; Otte, J.; Erickson, A.; Semsch, B.; Andersson, E.R.; Ratz, M.; Frisén, Jonas; Tischler, A.S.; de Krijger, R.R.; Bouderlique, T.; Akkuratova, N.; Vorontsova, M.; Gusev, O.; Fried, Kaj; Sundstrom, E.; Mei, S.; Kogner, P.; Baryawno, N.; Kharchenko, P.V.; Adameyko, Igor.

в: Nature Genetics, Том 53, № 5, 05.2021, стр. 694-706.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Kameneva, P, Artemov, AV, Kastriti, ME, Faure, L, Olsen, TK, Otte, J, Erickson, A, Semsch, B, Andersson, ER, Ratz, M, Frisén, J, Tischler, AS, de Krijger, RR, Bouderlique, T, Akkuratova, N, Vorontsova, M, Gusev, O, Fried, K, Sundstrom, E, Mei, S, Kogner, P, Baryawno, N, Kharchenko, PV & Adameyko, I 2021, 'Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin', Nature Genetics, Том. 53, № 5, стр. 694-706. https://doi.org/10.1038/s41588-021-00818-x

APA

Kameneva, P., Artemov, A. V., Kastriti, M. E., Faure, L., Olsen, T. K., Otte, J., Erickson, A., Semsch, B., Andersson, E. R., Ratz, M., Frisén, J., Tischler, A. S., de Krijger, R. R., Bouderlique, T., Akkuratova, N., Vorontsova, M., Gusev, O., Fried, K., Sundstrom, E., ... Adameyko, I. (2021). Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin. Nature Genetics, 53(5), 694-706. https://doi.org/10.1038/s41588-021-00818-x

Vancouver

Author

Kameneva, P. ; Artemov, A.V. ; Kastriti, Maria Eleni ; Faure, L. ; Olsen, T.K. ; Otte, J. ; Erickson, A. ; Semsch, B. ; Andersson, E.R. ; Ratz, M. ; Frisén, Jonas ; Tischler, A.S. ; de Krijger, R.R. ; Bouderlique, T. ; Akkuratova, N. ; Vorontsova, M. ; Gusev, O. ; Fried, Kaj ; Sundstrom, E. ; Mei, S. ; Kogner, P. ; Baryawno, N. ; Kharchenko, P.V. ; Adameyko, Igor. / Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin. в: Nature Genetics. 2021 ; Том 53, № 5. стр. 694-706.

BibTeX

@article{ee3445a3332d466b82dcebe280aee152,
title = "Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin",
abstract = "Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest– and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development. Our results reveal transitions connecting the intermediate mesoderm and progenitors of organ primordia, the hematopoietic system and endothelial subtypes. Unexpectedly, by using a combination of single-cell transcriptomics and lineage tracing, we found that intra-adrenal sympathoblasts at that stage are directly derived from nerve-associated Schwann cell precursors, similarly to local chromaffin cells, whereas the majority of extra-adrenal sympathoblasts arise from the migratory neural crest. In humans, this process persists during several weeks of development within the large intra-adrenal ganglia-like structures, which may also serve as reservoirs of originating cells in neuroblastoma.",
keywords = "Cancer, Computational biology and bioinformatics, Developmental biology, Embryonal neoplasms, Genetics, Schwann Cells/metabolism, Sympathoadrenal System/embryology, Chromaffin Cells/metabolism, Humans, Gene Expression Regulation, Neoplastic, Tumor Microenvironment, Infant, Embryonic Development, Neuroblastoma/embryology, Transcriptome/genetics, Embryo, Mammalian/metabolism, Cell Lineage, Animals, Neural Stem Cells/metabolism, Gene Expression Regulation, Developmental, Mice, Single-Cell Analysis, Cluster Analysis",
author = "P. Kameneva and A.V. Artemov and Kastriti, {Maria Eleni} and L. Faure and T.K. Olsen and J. Otte and A. Erickson and B. Semsch and E.R. Andersson and M. Ratz and Jonas Fris{\'e}n and A.S. Tischler and {de Krijger}, R.R. and T. Bouderlique and N. Akkuratova and M. Vorontsova and O. Gusev and Kaj Fried and E. Sundstrom and S. Mei and P. Kogner and N. Baryawno and P.V. Kharchenko and Igor Adameyko",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2021",
month = may,
doi = "10.1038/s41588-021-00818-x",
language = "English",
volume = "53",
pages = "694--706",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

AU - Kameneva, P.

AU - Artemov, A.V.

AU - Kastriti, Maria Eleni

AU - Faure, L.

AU - Olsen, T.K.

AU - Otte, J.

AU - Erickson, A.

AU - Semsch, B.

AU - Andersson, E.R.

AU - Ratz, M.

AU - Frisén, Jonas

AU - Tischler, A.S.

AU - de Krijger, R.R.

AU - Bouderlique, T.

AU - Akkuratova, N.

AU - Vorontsova, M.

AU - Gusev, O.

AU - Fried, Kaj

AU - Sundstrom, E.

AU - Mei, S.

AU - Kogner, P.

AU - Baryawno, N.

AU - Kharchenko, P.V.

AU - Adameyko, Igor

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2021/5

Y1 - 2021/5

N2 - Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest– and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development. Our results reveal transitions connecting the intermediate mesoderm and progenitors of organ primordia, the hematopoietic system and endothelial subtypes. Unexpectedly, by using a combination of single-cell transcriptomics and lineage tracing, we found that intra-adrenal sympathoblasts at that stage are directly derived from nerve-associated Schwann cell precursors, similarly to local chromaffin cells, whereas the majority of extra-adrenal sympathoblasts arise from the migratory neural crest. In humans, this process persists during several weeks of development within the large intra-adrenal ganglia-like structures, which may also serve as reservoirs of originating cells in neuroblastoma.

AB - Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest– and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development. Our results reveal transitions connecting the intermediate mesoderm and progenitors of organ primordia, the hematopoietic system and endothelial subtypes. Unexpectedly, by using a combination of single-cell transcriptomics and lineage tracing, we found that intra-adrenal sympathoblasts at that stage are directly derived from nerve-associated Schwann cell precursors, similarly to local chromaffin cells, whereas the majority of extra-adrenal sympathoblasts arise from the migratory neural crest. In humans, this process persists during several weeks of development within the large intra-adrenal ganglia-like structures, which may also serve as reservoirs of originating cells in neuroblastoma.

KW - Cancer

KW - Computational biology and bioinformatics

KW - Developmental biology

KW - Embryonal neoplasms

KW - Genetics

KW - Schwann Cells/metabolism

KW - Sympathoadrenal System/embryology

KW - Chromaffin Cells/metabolism

KW - Humans

KW - Gene Expression Regulation, Neoplastic

KW - Tumor Microenvironment

KW - Infant

KW - Embryonic Development

KW - Neuroblastoma/embryology

KW - Transcriptome/genetics

KW - Embryo, Mammalian/metabolism

KW - Cell Lineage

KW - Animals

KW - Neural Stem Cells/metabolism

KW - Gene Expression Regulation, Developmental

KW - Mice

KW - Single-Cell Analysis

KW - Cluster Analysis

UR - http://www.scopus.com/inward/record.url?scp=85104053714&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/4274f8a9-0eda-3aa4-a1e9-ae23c601cee9/

U2 - 10.1038/s41588-021-00818-x

DO - 10.1038/s41588-021-00818-x

M3 - Article

C2 - 33833454

VL - 53

SP - 694

EP - 706

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -

ID: 87436037