TY - JOUR

T1 - Sigma-1 receptor antagonist haloperidol attenuates Са2+ responses induced by glutoxim and molixan in macrophages

AU - Krutetskaya, Z.I.

AU - Milenina, L.S.

AU - Naumova, A.A.

AU - Butov, S.N.

AU - Antonov, V.G.

AU - Nozdrachev, A.D.

N1 - Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Sigma-1 receptor antagonist haloperidol attenuates Ca2+ responses induced by glutoxim and molixan in macrophages. Dokl Biochem Biophys 472, 74–76 (2017). https://doi.org/10.1134/S1607672917010227

PY - 2017

Y1 - 2017

N2 - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca2+-response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

AB - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca2+-response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

U2 - 10.1134/S1607672917010227

DO - 10.1134/S1607672917010227

M3 - Article

VL - 472

SP - 74

EP - 76

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -