TY - JOUR

T1 - Short-Term Consequences of Single Social Defeat on Accumbal Dopamine and Behaviors in Rats

AU - Nemets, Vsevolod V

AU - Deal, Alex L

AU - Sobolev, Vladislav E

AU - Grinevich, Vladimir P

AU - Gainetdinov, Raul R

AU - Budygin, Evgeny A

N1 - Nemets, V.V.; Deal, A.L.; Sobolev, V.E.; Grinevich, V.P.; Gainetdinov, R.R.; Budygin, E.A. Short-Term Consequences of Single Social Defeat on Accumbal Dopamine and Behaviors in Rats. Biomolecules 2023, 13, 35. https://doi.org/10.3390/biom13010035

PY - 2022/12/24

Y1 - 2022/12/24

N2 - The present study aimed to explore the consequences of a single exposure to a social defeat on dopamine release in the rat nucleus accumbens measured with a fast-scan cyclic voltammetry. We found that 24 h after a social defeat, accumbal dopamine responses, evoked by a high frequency electrical stimulation of the ventral tegmental area, were more profound in socially defeated rats in comparison with non-defeated control animals. The enhanced dopamine release was associated with the prolonged immobility time in the forced swim test. The use of the dopamine depletion protocol revealed no alteration in the reduction and recovery of the amplitude of dopamine release following social defeat stress. However, administration of dopamine D2 receptor antagonist, raclopride (2 mg/kg, i.p.), resulted in significant increase of the electrically evoked dopamine release in both groups of animals, nevertheless exhibiting less manifested effect in the defeated rats comparing to control animals. Taken together, our data demonstrated profound alterations in the dopamine transmission in the association with depressive-like behavior following a single exposure to stressful environment. These voltammetric findings pointed to a promising path for the identification of neurobiological mechanisms underlying stress-promoted behavioral abnormalities.

AB - The present study aimed to explore the consequences of a single exposure to a social defeat on dopamine release in the rat nucleus accumbens measured with a fast-scan cyclic voltammetry. We found that 24 h after a social defeat, accumbal dopamine responses, evoked by a high frequency electrical stimulation of the ventral tegmental area, were more profound in socially defeated rats in comparison with non-defeated control animals. The enhanced dopamine release was associated with the prolonged immobility time in the forced swim test. The use of the dopamine depletion protocol revealed no alteration in the reduction and recovery of the amplitude of dopamine release following social defeat stress. However, administration of dopamine D2 receptor antagonist, raclopride (2 mg/kg, i.p.), resulted in significant increase of the electrically evoked dopamine release in both groups of animals, nevertheless exhibiting less manifested effect in the defeated rats comparing to control animals. Taken together, our data demonstrated profound alterations in the dopamine transmission in the association with depressive-like behavior following a single exposure to stressful environment. These voltammetric findings pointed to a promising path for the identification of neurobiological mechanisms underlying stress-promoted behavioral abnormalities.

KW - Rats

KW - Animals

KW - Dopamine

KW - Social Defeat

KW - Nucleus Accumbens/physiology

KW - Raclopride/pharmacology

U2 - 10.3390/biom13010035

DO - 10.3390/biom13010035

M3 - Article

C2 - 36671420

VL - 13

JO - Biomolecules

JF - Biomolecules

SN - 2218-273X

IS - 1

M1 - 35

ER -