Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats. / Shcherbakova, Ksenia; Schwarz, Alexander; Ivleva, Irina; Nikitina, Veronika; Krytskaya, Darya; Apryatin, Sergey; Karpenko, Marina; Trofimov, Alexander.
в: Heliyon, Том 9, № 2, E13446, 01.02.2023.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats
AU - Shcherbakova, Ksenia
AU - Schwarz, Alexander
AU - Ivleva, Irina
AU - Nikitina, Veronika
AU - Krytskaya, Darya
AU - Apryatin, Sergey
AU - Karpenko, Marina
AU - Trofimov, Alexander
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Medium-chain triglycerides (MCT) possess neuroprotective properties. However, the long-term metabolic consequences of supplementing a regular diet with cognition-enhancing doses of MCT are largely unknown. We studied the effects of chronic (28 days) supplementation of regular diet with different doses of MCT oil (1, 3, or 6 g/kg/day) or water (control) on working memory (Y-maze), behavior in the Open Field, spatial learning (Morris water maze), and weight of internal organs in male Wistar 2.5-m.o. Rats. In a separate experiment, we evaluated acute (single gavage) and chronic (28 days) effects of MCT or lard supplementation (3 g/kg) on blood biochemical parameters. MCT-1 and MCT-3 doses improved working memory in YM. In MWM, MCT-6 treatment improved spatial memory. Chronic MCT-1 or MCT-3 treatment did not affect internal organ weight, while MCT-6 dose increased liver weight and the brown/white adipose tissue ratio. Acutely, MCT administration elevated blood β-hydroxybutyrate and malondialdehyde levels. Chronic MCT administration (3 g/kg) did not affect the blood levels of glucose, lactate, pyruvate, acetoacetate, β-hydroxybutyrate, total and HDL cholesterol, triglycerides, malondialdehyde, and aspartate transaminase and alanine transaminase activities. Therefore, daily supplementation of standard feed with MCT resulted in mild intermittent ketosis. It improved working memory at lower concentrations without significant adverse side effects. At higher concentrations, it improved long-term spatial memory but also resulted in organ weight changes and is likely unsafe. These results highlight the importance of monitoring the metabolic effects of MCT supplementation alongside cognitive assessment in future studies of MCT's neuroprotective properties.
AB - Medium-chain triglycerides (MCT) possess neuroprotective properties. However, the long-term metabolic consequences of supplementing a regular diet with cognition-enhancing doses of MCT are largely unknown. We studied the effects of chronic (28 days) supplementation of regular diet with different doses of MCT oil (1, 3, or 6 g/kg/day) or water (control) on working memory (Y-maze), behavior in the Open Field, spatial learning (Morris water maze), and weight of internal organs in male Wistar 2.5-m.o. Rats. In a separate experiment, we evaluated acute (single gavage) and chronic (28 days) effects of MCT or lard supplementation (3 g/kg) on blood biochemical parameters. MCT-1 and MCT-3 doses improved working memory in YM. In MWM, MCT-6 treatment improved spatial memory. Chronic MCT-1 or MCT-3 treatment did not affect internal organ weight, while MCT-6 dose increased liver weight and the brown/white adipose tissue ratio. Acutely, MCT administration elevated blood β-hydroxybutyrate and malondialdehyde levels. Chronic MCT administration (3 g/kg) did not affect the blood levels of glucose, lactate, pyruvate, acetoacetate, β-hydroxybutyrate, total and HDL cholesterol, triglycerides, malondialdehyde, and aspartate transaminase and alanine transaminase activities. Therefore, daily supplementation of standard feed with MCT resulted in mild intermittent ketosis. It improved working memory at lower concentrations without significant adverse side effects. At higher concentrations, it improved long-term spatial memory but also resulted in organ weight changes and is likely unsafe. These results highlight the importance of monitoring the metabolic effects of MCT supplementation alongside cognitive assessment in future studies of MCT's neuroprotective properties.
KW - Cholesterol
KW - Ketosis
KW - Malondialdehyde
KW - Medium-chain triglycerides
KW - Metabolic health
KW - Neuroprotection
KW - Spatial memory
KW - Working memory
UR - https://www.mendeley.com/catalogue/1c2f2cf0-46fd-3554-b9c3-bbffdfa4154c/
U2 - 10.1016/j.heliyon.2023.e13446
DO - 10.1016/j.heliyon.2023.e13446
M3 - Article
C2 - 36825166
VL - 9
JO - Heliyon
JF - Heliyon
SN - 2405-8440
IS - 2
M1 - E13446,
ER -
ID: 115015252