Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment

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Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment. / Dos Santos, Bruna E.; Giacomini, Ana C. V. V.; Marcon, Leticia; Demin, Konstantin A; Strekalova, Tatyana; de Abreu, Murilo S; Kalueff, Allan V.

в: Neuroscience Letters, Том 759, 135993, 10.08.2021.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Dos Santos, Bruna E. ; Giacomini, Ana C. V. V. ; Marcon, Leticia ; Demin, Konstantin A ; Strekalova, Tatyana ; de Abreu, Murilo S ; Kalueff, Allan V. / Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment. в: Neuroscience Letters. 2021 ; Том 759.

BibTeX

@article{5fbaea15aa494a2ab83b75b6ac05fd92,

title = "Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment",

abstract = "Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-μM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.",

keywords = "temperament, scopolamine, zebrafish, Sex differences, anxiety-like behavior, locomotion, Locomotion, Scopolamine, Anxiety-like behavior, Zebrafish, Temperament, DEPRESSION, TEMPERAMENT, ACETYLCHOLINE-RELEASE PROFILE, BOLDNESS, INDIVIDUAL-DIFFERENCES, MODELS, BEHAVIORAL SYNDROMES, STRESS, AGGRESSION, GENDER-DIFFERENCES",

author = "{Dos Santos}, {Bruna E.} and Giacomini, {Ana C. V. V.} and Leticia Marcon and Demin, {Konstantin A} and Tatyana Strekalova and {de Abreu}, {Murilo S} and Kalueff, {Allan V}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = aug,

day = "10",

doi = "10.1016/j.neulet.2021.135993",

language = "English",

volume = "759",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment

AU - Dos Santos, Bruna E.

AU - Giacomini, Ana C. V. V.

AU - Marcon, Leticia

AU - Demin, Konstantin A

AU - Strekalova, Tatyana

AU - de Abreu, Murilo S

AU - Kalueff, Allan V

PY - 2021/8/10

Y1 - 2021/8/10

N2 - Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-μM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.

AB - Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-μM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.

KW - temperament

KW - scopolamine

KW - zebrafish

KW - Sex differences

KW - anxiety-like behavior

KW - locomotion

KW - Locomotion

KW - Scopolamine

KW - Anxiety-like behavior

KW - Zebrafish

KW - Temperament

KW - DEPRESSION

KW - TEMPERAMENT

KW - ACETYLCHOLINE-RELEASE PROFILE

KW - BOLDNESS

KW - INDIVIDUAL-DIFFERENCES

KW - MODELS

KW - BEHAVIORAL SYNDROMES

KW - STRESS

KW - AGGRESSION

KW - GENDER-DIFFERENCES

UR - http://www.scopus.com/inward/record.url?scp=85108336314&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/819542be-e4a6-374d-9271-c0bfbe9b403a/

U2 - 10.1016/j.neulet.2021.135993

DO - 10.1016/j.neulet.2021.135993

M3 - Article

C2 - 34058290

VL - 759

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

M1 - 135993

ER -

ID: 77731991