Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Sex differences in adult zebrafish anxiolytic-like responses to diazepam and melatonin. / Genario, Rafael; Giacomini, Ana C V V; de Abreu, Murilo S; Marcon, Leticia; Demin, Konstantin A; Kalueff, Allan V.
в: Neuroscience Letters, Том 714, 134548, 01.01.2020, стр. 134548.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Sex differences in adult zebrafish anxiolytic-like responses to diazepam and melatonin
AU - Genario, Rafael
AU - Giacomini, Ana C V V
AU - de Abreu, Murilo S
AU - Marcon, Leticia
AU - Demin, Konstantin A
AU - Kalueff, Allan V
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Sex differences are an important variable in biomedical research. The zebrafish (Danio rerio) is rapidly becoming a critical novel model organism in translational neuroscience and neuropharmacology. Here, we examine the effects of sex on locomotor activity and anxiety-like behavior in adult zebrafish tested in the novel tank test following their exposure to two clinically relevant, common anxiolytic drugs diazepam and melatonin. While control female zebrafish were more active and anxious than males, both sexes showed anxiolytic responses to melatonin (0.232 mg/L) but only males responded to diazepam (16 μg/L). Revealing sex specificity in pharmacological responses, this study emphasizes the importance of sex differences in behavioral and pharmacological analyses in zebrafish. This may also be potentially relevant to modeling sex differences in clinical responses to anxiolytic drugs. Collectively, our data support sex differences in zebrafish behavioral responses and reinforce the growing utility of this aquatic model in CNS drug screening.
AB - Sex differences are an important variable in biomedical research. The zebrafish (Danio rerio) is rapidly becoming a critical novel model organism in translational neuroscience and neuropharmacology. Here, we examine the effects of sex on locomotor activity and anxiety-like behavior in adult zebrafish tested in the novel tank test following their exposure to two clinically relevant, common anxiolytic drugs diazepam and melatonin. While control female zebrafish were more active and anxious than males, both sexes showed anxiolytic responses to melatonin (0.232 mg/L) but only males responded to diazepam (16 μg/L). Revealing sex specificity in pharmacological responses, this study emphasizes the importance of sex differences in behavioral and pharmacological analyses in zebrafish. This may also be potentially relevant to modeling sex differences in clinical responses to anxiolytic drugs. Collectively, our data support sex differences in zebrafish behavioral responses and reinforce the growing utility of this aquatic model in CNS drug screening.
KW - Anxiety
KW - Diazepam
KW - Emotional behavior
KW - Melatonin
KW - Sedation
KW - Sex differences
KW - DEPRESSION
KW - DRUG DISCOVERY
KW - ANXIETY-LIKE BEHAVIOR
KW - PHARMACOLOGICAL-TREATMENT
KW - MODELS
KW - FEMALE RATS
KW - MICE
KW - NEUROSCIENCE RESEARCH
KW - STRESS
KW - GENDER-DIFFERENCES
UR - http://www.scopus.com/inward/record.url?scp=85074044492&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/sex-differences-adult-zebrafish-anxiolyticlike-responses-diazepam-melatonin
U2 - 10.1016/j.neulet.2019.134548
DO - 10.1016/j.neulet.2019.134548
M3 - Article
C2 - 31629774
VL - 714
SP - 134548
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
M1 - 134548
ER -
ID: 48951887