Age-related changes and sexual differences of some of the morphometric characteristics of the lower part of facial skeleton were studied. It was shown that the height of the face lower part in the skulls with intact orthognathic occlusion remained unchanged during the age period from 22 to 70 years. In both men and women with full dentition and orthognathic occlusion aged from 22 to 35 years, the significant decrease was observed in the angle of the ramus of mandible due to the bone tissue formation in this region. The parameters of the height of the ramus of mandible, the projection height of the mandibular condylar process, and the least width of the mandibular ramus in men and women have significant age- and sex-related differences.