TY - JOUR

T1 - Sequential steps in clathrin-mediated synaptic vesicle endocytosis

AU - Brodin, Lennart

AU - Löw, Peter

AU - Shupliakov, Oleg

PY - 2000/6/1

Y1 - 2000/6/1

N2 - Synaptic vesicles are recycled with remarkable speed and precision in nerve terminals. A major recycling pathway involves clathrin-mediated endocytosis at endocytic zones located around sites of release. Different 'accessory' proteins linked to this pathway have been shown to alter the shape and composition of lipid membranes, to modify membrane-coat protein interactions, and to influence actin polymerization. These include the GTPase dynamin, the lysophosphatidic acid acyl transferase endophilin, and the phosphoinositide phosphatase synaptojanin. Protein perturbation studies in living nerve terminals are now beginning to link the actions of these proteins with morphologically defined steps of endocytosis.

AB - Synaptic vesicles are recycled with remarkable speed and precision in nerve terminals. A major recycling pathway involves clathrin-mediated endocytosis at endocytic zones located around sites of release. Different 'accessory' proteins linked to this pathway have been shown to alter the shape and composition of lipid membranes, to modify membrane-coat protein interactions, and to influence actin polymerization. These include the GTPase dynamin, the lysophosphatidic acid acyl transferase endophilin, and the phosphoinositide phosphatase synaptojanin. Protein perturbation studies in living nerve terminals are now beginning to link the actions of these proteins with morphologically defined steps of endocytosis.

UR - http://www.scopus.com/inward/record.url?scp=0342748583&partnerID=8YFLogxK

U2 - 10.1016/S0959-4388(00)00097-0

DO - 10.1016/S0959-4388(00)00097-0

M3 - Review article

C2 - 10851177

AN - SCOPUS:0342748583

VL - 10

SP - 312

EP - 320

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

IS - 3

ER -