TY - JOUR

T1 - Semidominant effect of the l(1)ts403 (sbr 10) mutation on sex chromosome nondsjunction in meiosis in Drosophila melanogaster females exposed to heat

AU - Nikitina, E. A.

AU - Komarova, A. V.

AU - Golubkova, E. V.

AU - Tretyakova, I. V.

AU - Mamon, L. A.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - The sbr gene of Drosophila melanogaster belongs to the NXF (nuclear export factor) family responsible for the mRNA transport from nucleus to cytoplasm. We have shown that in the heat-exposed (37°C, 1 h) females, the l(1)ts403 (sbr 10) mutation leads, in particular, to the high-frequency nondisjunction and loss of sex chromosomes in meiosis. For this trait, the incomplete dominance of the sbr 10 mutation is observed. At the same time, the sbr 10 mutation is recessive for many other traits of the heat-exposed flies: reduced viability, low fertility, impaired synthesis of the heat shock proteins, etc. The females heterozygous for the null allele (Df(1)v L4, a deletion eliminating gene srb) do not differ from females homozygous for the wild-type allele in frequency of the heat shock-induced nondisjunction and loss of sex chromosomes in meiosis. Because of this, the sbr 10 mutation can be assigned to the gain-of-function alleles (those gaining the dominance function). Expression of the mutant sbr 10 allele against the background of the wild-type allele suggests that in the heat shock-exposed females, the heat-modified product of this ts allele has an active effect on sex chromosome disjunction in meiosis.

AB - The sbr gene of Drosophila melanogaster belongs to the NXF (nuclear export factor) family responsible for the mRNA transport from nucleus to cytoplasm. We have shown that in the heat-exposed (37°C, 1 h) females, the l(1)ts403 (sbr 10) mutation leads, in particular, to the high-frequency nondisjunction and loss of sex chromosomes in meiosis. For this trait, the incomplete dominance of the sbr 10 mutation is observed. At the same time, the sbr 10 mutation is recessive for many other traits of the heat-exposed flies: reduced viability, low fertility, impaired synthesis of the heat shock proteins, etc. The females heterozygous for the null allele (Df(1)v L4, a deletion eliminating gene srb) do not differ from females homozygous for the wild-type allele in frequency of the heat shock-induced nondisjunction and loss of sex chromosomes in meiosis. Because of this, the sbr 10 mutation can be assigned to the gain-of-function alleles (those gaining the dominance function). Expression of the mutant sbr 10 allele against the background of the wild-type allele suggests that in the heat shock-exposed females, the heat-modified product of this ts allele has an active effect on sex chromosome disjunction in meiosis.

UR - http://www.scopus.com/inward/record.url?scp=9444270382&partnerID=8YFLogxK

U2 - 10.1023/A:1023208725228

DO - 10.1023/A:1023208725228

M3 - Article

AN - SCOPUS:9444270382

VL - 39

SP - 269

EP - 275

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 3

ER -