TY - JOUR

T1 - Secure application of graphene in medicine

AU - Savicheva, Alevtina

AU - Tapilskaya, Natalya

AU - Spasibova, Elena

AU - Gzgzyan, Alexander

AU - Kogan, Igor

AU - Shalepo, Kira

AU - Vorobiev, Sergey

AU - Kirichek, Ruslan

AU - Pirmagomedov, Rustam

AU - Rybin, Maxim

AU - Glushakov, Ruslan

N1 - Publisher Copyright: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the UR MED GRUPP (LLC). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - The unique physical properties considered of graphene to be especially perspective for photothermal therapy complex, drug address delivery to the target organs, and some other fields. Objective: The objective of our study was to explore the possible graphene impact on microorganism growth as well as on laboratory animal overall condition. Materials and technique: The experiments applied samples of graphene three concentrations and two 15 × 15 mm quartz glasses one of which carrying deposited graphene lattice. We have also used 5% blood agar, thioglycollate broth, bacterial suspensions of standard turbidity containing pure clinical isolate of microorganisms. Three white male 6-month-old laboratory rats were used to estimate the graphene impact on the overall animal condition. Results: Graphene did not contain any microorganisms, does not destroy erythrocytes placed within the artificial nutritional medium, graphene lattice did not add any properties to the quartz glasses which could allow the Proteus spread all over its surface. It was also established that graphene did not show any native antibacterial impact. No significant reaction was noticed in animals after graphene administration to laboratory rats neither at the injection spot nor at the overall level. Conclusion: Our data confirm the applicability of graphene both in scientific and practical biomedical purposes.

AB - The unique physical properties considered of graphene to be especially perspective for photothermal therapy complex, drug address delivery to the target organs, and some other fields. Objective: The objective of our study was to explore the possible graphene impact on microorganism growth as well as on laboratory animal overall condition. Materials and technique: The experiments applied samples of graphene three concentrations and two 15 × 15 mm quartz glasses one of which carrying deposited graphene lattice. We have also used 5% blood agar, thioglycollate broth, bacterial suspensions of standard turbidity containing pure clinical isolate of microorganisms. Three white male 6-month-old laboratory rats were used to estimate the graphene impact on the overall animal condition. Results: Graphene did not contain any microorganisms, does not destroy erythrocytes placed within the artificial nutritional medium, graphene lattice did not add any properties to the quartz glasses which could allow the Proteus spread all over its surface. It was also established that graphene did not show any native antibacterial impact. No significant reaction was noticed in animals after graphene administration to laboratory rats neither at the injection spot nor at the overall level. Conclusion: Our data confirm the applicability of graphene both in scientific and practical biomedical purposes.

KW - graphene, medicine, microorganisms, animal condition

UR - http://www.scopus.com/inward/record.url?scp=85097488479&partnerID=8YFLogxK

U2 - 10.1080/09513590.2020.1816717

DO - 10.1080/09513590.2020.1816717

M3 - Article

C2 - 33305673

AN - SCOPUS:85097488479

VL - 36

SP - 48

EP - 52

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

SN - 0951-3590

IS - S1

ER -