TY - JOUR

T1 - Secondary Metabolome Variability and Inducible Chemical Defenses in the Mediterranean Sponge Aplysina cavernicola

AU - Reverter, M.

AU - Perez, T.

AU - Ereskovsky, A. V.

AU - Banaigs, B.

PY - 2016

Y1 - 2016

N2 - Secondary metabolites play a crucial role in marine invertebrates chemical ecology, and it is thus of great importance to understand factors regulating their production and sources of variability. This work aimed to study the bromotyrosine derivatives variability in the Mediterranean sponge Aplysina cavernicola and to better understand how biotic (reproductive state) and abiotic factors (seawater temperature) could partly explain this variability. Results showed that A. cavernicola reproductive cycle has little effect on the variability of the sponge secondary metabolism, whereas water temperature has a significant influence on the production level of secondary metabolites. Analysis of the temporal variability of the sponge methanolic extracts bioactivity showed that bioactivity variability was related to the presence of the minor secondary metabolite dienone, which accounted for 50% of the bioactivity observed. Further bioassays coupled to HPLC extract fractionation confirmed that dienone was the only compou

AB - Secondary metabolites play a crucial role in marine invertebrates chemical ecology, and it is thus of great importance to understand factors regulating their production and sources of variability. This work aimed to study the bromotyrosine derivatives variability in the Mediterranean sponge Aplysina cavernicola and to better understand how biotic (reproductive state) and abiotic factors (seawater temperature) could partly explain this variability. Results showed that A. cavernicola reproductive cycle has little effect on the variability of the sponge secondary metabolism, whereas water temperature has a significant influence on the production level of secondary metabolites. Analysis of the temporal variability of the sponge methanolic extracts bioactivity showed that bioactivity variability was related to the presence of the minor secondary metabolite dienone, which accounted for 50% of the bioactivity observed. Further bioassays coupled to HPLC extract fractionation confirmed that dienone was the only compou

KW - Aplysina sponges

KW - Secondary metabolites

KW - Bioactivity

KW - Temporal variation

KW - Intraspecific variations

KW - Reproductive cycle

KW - Dynamic chemical defense

KW - Dienone

KW - morphogenesis

U2 - 10.1007/s10886-015-0664-9

DO - 10.1007/s10886-015-0664-9

M3 - Article

VL - 42

SP - 60

EP - 70

JO - Journal of Chemical Ecology

JF - Journal of Chemical Ecology

SN - 0098-0331

IS - 1

ER -