Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis

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Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis. / Jarzebska, Natalia; Karetnikova, Ekaterina S.; Markov, Alexander G.; Kasper, Michael; Rodionov, Roman N.; Spieth, Peter M.

в: Frontiers in Medicine, Том 7, 585756, 15.01.2021.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Author

Jarzebska, Natalia ; Karetnikova, Ekaterina S. ; Markov, Alexander G. ; Kasper, Michael ; Rodionov, Roman N. ; Spieth, Peter M. / Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis. в: Frontiers in Medicine. 2021 ; Том 7.

BibTeX

@article{4199080192ba44ab872e67fa78203b22,

title = "Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis",

abstract = "Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.",

keywords = "dimethylarginine dimethylaminohydrolase, macromolecular damage, nitric oxide, pulmonary fibrosis, radiation, PROTON-BEAM THERAPY, STEM-CELLS, INTERCELLULAR-ADHESION MOLECULE-1, RISK-FACTORS, CANCER-ASSOCIATED FIBROBLASTS, ASYMMETRIC DIMETHYLARGININE, INJURY, TO-MESENCHYMAL TRANSITION, EMERGING ROLE, STEREOTACTIC BODY RADIOTHERAPY",

author = "Natalia Jarzebska and Karetnikova, {Ekaterina S.} and Markov, {Alexander G.} and Michael Kasper and Rodionov, {Roman N.} and Spieth, {Peter M.}",

note = "Funding Information: Funding. This review was supported by the Partnership Program Technische Universit?t Dresden ? Saint Petersburg State University. Open Access Funding by the Publication Fund of the TU Dresden. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Jarzebska, Karetnikova, Markov, Kasper, Rodionov and Spieth. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

day = "15",

doi = "10.3389/fmed.2020.585756",

language = "English",

volume = "7",

journal = "Frontiers in Medicine",

issn = "2296-858X",

publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis

AU - Jarzebska, Natalia

AU - Karetnikova, Ekaterina S.

AU - Markov, Alexander G.

AU - Kasper, Michael

AU - Rodionov, Roman N.

AU - Spieth, Peter M.

N1 - Funding Information: Funding. This review was supported by the Partnership Program Technische Universit?t Dresden ? Saint Petersburg State University. Open Access Funding by the Publication Fund of the TU Dresden. Publisher Copyright: © Copyright © 2021 Jarzebska, Karetnikova, Markov, Kasper, Rodionov and Spieth. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/15

Y1 - 2021/1/15

N2 - Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.

AB - Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.

KW - dimethylarginine dimethylaminohydrolase

KW - macromolecular damage

KW - nitric oxide

KW - pulmonary fibrosis

KW - radiation

KW - PROTON-BEAM THERAPY

KW - STEM-CELLS

KW - INTERCELLULAR-ADHESION MOLECULE-1

KW - RISK-FACTORS

KW - CANCER-ASSOCIATED FIBROBLASTS

KW - ASYMMETRIC DIMETHYLARGININE

KW - INJURY

KW - TO-MESENCHYMAL TRANSITION

KW - EMERGING ROLE

KW - STEREOTACTIC BODY RADIOTHERAPY

UR - http://www.scopus.com/inward/record.url?scp=85100189859&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/c6328007-1bb0-30f3-9bbd-d5f1e9cc030e/

U2 - 10.3389/fmed.2020.585756

DO - 10.3389/fmed.2020.585756

M3 - Review article

AN - SCOPUS:85100189859

VL - 7

JO - Frontiers in Medicine

JF - Frontiers in Medicine

SN - 2296-858X

M1 - 585756

ER -

ID: 73954553

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