Standard

Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety. / Tarasenko, Marina; Duderin, Nikolay; Sharonova, Tatyana; Baykov, Sergey; Shetnev, Anton; Smirnov, Alexey V.

в: Tetrahedron Letters, Том 58, № 37, 13.09.2017, стр. 3672-3677.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Tarasenko, M, Duderin, N, Sharonova, T, Baykov, S, Shetnev, A & Smirnov, AV 2017, 'Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety', Tetrahedron Letters, Том. 58, № 37, стр. 3672-3677. https://doi.org/10.1016/j.tetlet.2017.08.020

APA

Tarasenko, M., Duderin, N., Sharonova, T., Baykov, S., Shetnev, A., & Smirnov, A. V. (2017). Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety. Tetrahedron Letters, 58(37), 3672-3677. https://doi.org/10.1016/j.tetlet.2017.08.020

Vancouver

Tarasenko M, Duderin N, Sharonova T, Baykov S, Shetnev A, Smirnov AV. Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety. Tetrahedron Letters. 2017 Сент. 13;58(37):3672-3677. https://doi.org/10.1016/j.tetlet.2017.08.020

Author

Tarasenko, Marina ; Duderin, Nikolay ; Sharonova, Tatyana ; Baykov, Sergey ; Shetnev, Anton ; Smirnov, Alexey V. / Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety. в: Tetrahedron Letters. 2017 ; Том 58, № 37. стр. 3672-3677.

BibTeX

@article{603fbe3ba747412bade86f5dfee89178,
title = "Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety",
abstract = "An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.",
keywords = "Anhydride, Carboxylic acid, Heterocycles, Room temperature synthesis, Superbase catalysis",
author = "Marina Tarasenko and Nikolay Duderin and Tatyana Sharonova and Sergey Baykov and Anton Shetnev and Smirnov, {Alexey V.}",
year = "2017",
month = sep,
day = "13",
doi = "10.1016/j.tetlet.2017.08.020",
language = "English",
volume = "58",
pages = "3672--3677",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "37",

}

RIS

TY - JOUR

T1 - Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety

AU - Tarasenko, Marina

AU - Duderin, Nikolay

AU - Sharonova, Tatyana

AU - Baykov, Sergey

AU - Shetnev, Anton

AU - Smirnov, Alexey V.

PY - 2017/9/13

Y1 - 2017/9/13

N2 - An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.

AB - An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.

KW - Anhydride

KW - Carboxylic acid

KW - Heterocycles

KW - Room temperature synthesis

KW - Superbase catalysis

UR - http://www.scopus.com/inward/record.url?scp=85027584411&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2017.08.020

DO - 10.1016/j.tetlet.2017.08.020

M3 - Article

AN - SCOPUS:85027584411

VL - 58

SP - 3672

EP - 3677

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 37

ER -

ID: 41034350