TY - JOUR

T1 - Role of the oral microbiota in the development of Alzheimer’s disease

AU - Гаврилова, Наталия Юрьевна

AU - Гладышев, Никита Сергеевич

AU - Котрова, Анна Дмитриевна

AU - Морозова, Анастасия Сергеевна

AU - Сопрун, Лидия Александровна

AU - Воловникова, Виктория Александровна

AU - Федоткина, Тамара Викторовна

AU - Шишкин, Александр Николаевич

PY - 2020

Y1 - 2020

N2 - Dementia and, in particular, Alzheimer’s disease (AD), affects millions of people around theworld and its prevalence is steadily rising annually. Some risk factors for AD, such as age, cannot be modified, while others could possibly be corrected. In recent years, many studies aretackling the problem of the oral and gut microbiota as a provoking factor for AD and otherneurodegenerative diseases, but their relationship and specific pathophysiological mechanisms remain understudied. The microbiota of the oral cavity can be of particular importancedue to the specificity of microorganisms and their localization, as well as the possibility ofprovoking neuroinflammation, which requires further study. This review covers the specificfeatures of the oral microbiota, current views on the pathophysiological role of the oral microbiota in the development of AD, as well as the beneficial role of probiotics. The study of thisissue can have an important practical application both for the early diagnosis of AD, and forits further treatment.

AB - Dementia and, in particular, Alzheimer’s disease (AD), affects millions of people around theworld and its prevalence is steadily rising annually. Some risk factors for AD, such as age, cannot be modified, while others could possibly be corrected. In recent years, many studies aretackling the problem of the oral and gut microbiota as a provoking factor for AD and otherneurodegenerative diseases, but their relationship and specific pathophysiological mechanisms remain understudied. The microbiota of the oral cavity can be of particular importancedue to the specificity of microorganisms and their localization, as well as the possibility ofprovoking neuroinflammation, which requires further study. This review covers the specificfeatures of the oral microbiota, current views on the pathophysiological role of the oral microbiota in the development of AD, as well as the beneficial role of probiotics. The study of thisissue can have an important practical application both for the early diagnosis of AD, and forits further treatment.

KW - Alzheimer’s disease

KW - oral cavity

KW - microbiota

KW - probiotics

KW - neurodegenerative diseases

UR - https://www.mendeley.com/catalogue/bb8142ff-6f6c-3804-8522-ec95c721bfd6/

U2 - 10.21638/spbu11.2020.401

DO - 10.21638/spbu11.2020.401

M3 - Article

VL - 15

SP - 231

EP - 238

JO - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

JF - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

SN - 1818-2909

IS - 4

ER -