TY - JOUR

T1 - Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction

AU - Silanteva, Irina A.

AU - Komolkin, Andrei V.

AU - Morozova, Ekaterina A.

AU - Vorontsov-Velyaminov, Pavel N.

AU - Kasyanenko, Nina A.

PY - 2019/3/7

Y1 - 2019/3/7

N2 - The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine. It was observed that Mg2+ ions can promote DNA-EDR interaction due to their effective screening of the negatively charged phosphate groups of DNA. This action of Mg2+ remains in salted solution as well.

AB - The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine. It was observed that Mg2+ ions can promote DNA-EDR interaction due to their effective screening of the negatively charged phosphate groups of DNA. This action of Mg2+ remains in salted solution as well.

KW - MOLECULAR-DYNAMICS

KW - EXPRESSION

KW - STABILITY

KW - PROTEINS

KW - BINDING

KW - ACIDS

UR - http://www.scopus.com/inward/record.url?scp=85062604380&partnerID=8YFLogxK

U2 - 10.1021/acs.jpcb.8b10359

DO - 10.1021/acs.jpcb.8b10359

M3 - Article

C2 - 30762356

AN - SCOPUS:85062604380

VL - 123

SP - 1896

EP - 1902

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

SN - 1520-6106

IS - 9

ER -