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Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii. / Abu Asali, I. I.; Rozanov, V. A.; Rozanov, A. I.

в: Ukrainskii biokhimicheskii zhurnal, Том 64, № 1, 01.01.1992, стр. 77-82.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Abu Asali, II, Rozanov, VA & Rozanov, AI 1992, 'Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii.', Ukrainskii biokhimicheskii zhurnal, Том. 64, № 1, стр. 77-82.

APA

Abu Asali, I. I., Rozanov, V. A., & Rozanov, A. I. (1992). Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii. Ukrainskii biokhimicheskii zhurnal, 64(1), 77-82.

Vancouver

Abu Asali II, Rozanov VA, Rozanov AI. Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii. Ukrainskii biokhimicheskii zhurnal. 1992 Янв. 1;64(1):77-82.

Author

Abu Asali, I. I. ; Rozanov, V. A. ; Rozanov, A. I. / Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii. в: Ukrainskii biokhimicheskii zhurnal. 1992 ; Том 64, № 1. стр. 77-82.

BibTeX

@article{eb193688ee784a6da078663b3d2abd67,
title = "Rol' transaminaz v realizatsii zashchitnogo {\'e}ffekta L-aspartata pri gipoksii.",
abstract = "Activation of aspartate aminotransferase and alanine aminotransferase of mitochondria introduced to the incubation medium of pyridoxal-5'-phosphate (40 microM) is approximately 2 times higher than that of the corresponding cytoplasmic forms. At hypoxia aspartate aminotransferase activity in mitochondria and postmitochondrial supernatant tends to an increase while that of alanine aminotransferase decreases (above 2 times). The protection from hypoxic damage when using L-aspartate (100 mg/kg subcutaneously 3-5 min before hypoxia) intensifies an adaptive increase of aspartate aminotransferase activity and removes a decrease of alanine aminotransferase activity. Under these conditions stimulating effect of pyridoxal-5'-phosphate on transaminases activity in vitro weakens. A simultaneous administration of vitamin-coenzyme complex (thiamine pyrophosphate, lipoate, sodium 4-phospho-pantothenate, flavin-mononucleotide, nicotinate) intensifies these metabolic shifts and protective action of L-aspartate.",
author = "{Abu Asali}, {I. I.} and Rozanov, {V. A.} and Rozanov, {A. I.}",
year = "1992",
month = jan,
day = "1",
language = "русский",
volume = "64",
pages = "77--82",
journal = "Ukrainian biochemical journal",
issn = "2409-4943",
publisher = "Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine (NASU)",
number = "1",

}

RIS

TY - JOUR

T1 - Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii.

AU - Abu Asali, I. I.

AU - Rozanov, V. A.

AU - Rozanov, A. I.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Activation of aspartate aminotransferase and alanine aminotransferase of mitochondria introduced to the incubation medium of pyridoxal-5'-phosphate (40 microM) is approximately 2 times higher than that of the corresponding cytoplasmic forms. At hypoxia aspartate aminotransferase activity in mitochondria and postmitochondrial supernatant tends to an increase while that of alanine aminotransferase decreases (above 2 times). The protection from hypoxic damage when using L-aspartate (100 mg/kg subcutaneously 3-5 min before hypoxia) intensifies an adaptive increase of aspartate aminotransferase activity and removes a decrease of alanine aminotransferase activity. Under these conditions stimulating effect of pyridoxal-5'-phosphate on transaminases activity in vitro weakens. A simultaneous administration of vitamin-coenzyme complex (thiamine pyrophosphate, lipoate, sodium 4-phospho-pantothenate, flavin-mononucleotide, nicotinate) intensifies these metabolic shifts and protective action of L-aspartate.

AB - Activation of aspartate aminotransferase and alanine aminotransferase of mitochondria introduced to the incubation medium of pyridoxal-5'-phosphate (40 microM) is approximately 2 times higher than that of the corresponding cytoplasmic forms. At hypoxia aspartate aminotransferase activity in mitochondria and postmitochondrial supernatant tends to an increase while that of alanine aminotransferase decreases (above 2 times). The protection from hypoxic damage when using L-aspartate (100 mg/kg subcutaneously 3-5 min before hypoxia) intensifies an adaptive increase of aspartate aminotransferase activity and removes a decrease of alanine aminotransferase activity. Under these conditions stimulating effect of pyridoxal-5'-phosphate on transaminases activity in vitro weakens. A simultaneous administration of vitamin-coenzyme complex (thiamine pyrophosphate, lipoate, sodium 4-phospho-pantothenate, flavin-mononucleotide, nicotinate) intensifies these metabolic shifts and protective action of L-aspartate.

UR - http://www.scopus.com/inward/record.url?scp=0026494555&partnerID=8YFLogxK

M3 - статья

C2 - 1519351

AN - SCOPUS:0026494555

VL - 64

SP - 77

EP - 82

JO - Ukrainian biochemical journal

JF - Ukrainian biochemical journal

SN - 2409-4943

IS - 1

ER -

ID: 42769464