TY - JOUR

T1 - Risk of alzheimer’s disease in cancer patients: Analysis of mortality data from the US SEER population-based registries

AU - Mezencev, Roman

AU - Chernoff, Yury O.

N1 - Mezencev, R.; Chernoff, Y.O. Risk of Alzheimer’s Disease in Cancer Patients: Analysis of Mortality Data from the US SEER Population-Based Registries. Cancers 2020, 12, 796.

PY - 2020/4

Y1 - 2020/4

N2 - Previous studies have reported an inverse association between cancer and Alzheimer’s disease (AD), which are leading causes of human morbidity and mortality. We analyzed the SEER (Surveillance, Epidemiology, and End Results) data to estimate the risk of AD death in (i) cancer patients relative to reference populations stratified on demographic and clinical variables, and (ii) female breast cancer (BC) patients treated with chemotherapy or radiotherapy, relative to those with no/unknown treatment status. Our results demonstrate the impact of race, cancer type, age and time since cancer diagnosis on the risk of AD death in cancer patients. While the risk of AD death was decreased in white patients diagnosed with various cancers at 45 or more years of age, it was increased in black patients diagnosed with cancers before 45 years of age (likely due to early onset AD). Chemotherapy decreased the risk of AD death in white women diagnosed with BC at the age of 65 or more, however radiotherapy displayed a more complex pattern with early decrease and late increase in the risk of AD death during a prolonged time interval after the treatment. Our data point to links between molecular mechanisms involved in cancer and AD, and to the potential applicability of some anti-cancer treatments against AD.

AB - Previous studies have reported an inverse association between cancer and Alzheimer’s disease (AD), which are leading causes of human morbidity and mortality. We analyzed the SEER (Surveillance, Epidemiology, and End Results) data to estimate the risk of AD death in (i) cancer patients relative to reference populations stratified on demographic and clinical variables, and (ii) female breast cancer (BC) patients treated with chemotherapy or radiotherapy, relative to those with no/unknown treatment status. Our results demonstrate the impact of race, cancer type, age and time since cancer diagnosis on the risk of AD death in cancer patients. While the risk of AD death was decreased in white patients diagnosed with various cancers at 45 or more years of age, it was increased in black patients diagnosed with cancers before 45 years of age (likely due to early onset AD). Chemotherapy decreased the risk of AD death in white women diagnosed with BC at the age of 65 or more, however radiotherapy displayed a more complex pattern with early decrease and late increase in the risk of AD death during a prolonged time interval after the treatment. Our data point to links between molecular mechanisms involved in cancer and AD, and to the potential applicability of some anti-cancer treatments against AD.

KW - Alzheimer’s disease

KW - BRCA1

KW - Cancer

KW - Chemotherapy

KW - Early-Onset Alzheimer’s disease

KW - Late-Onset Alzheimer’s disease

KW - Mortality

KW - Radiotherapy

KW - SEER

KW - SURVIVAL

KW - DEMENTIA

KW - chemotherapy

KW - Late-Onset Alzheimer's disease

KW - BREAST-CANCER

KW - Alzheimer's disease

KW - UNITED-STATES

KW - DIAGNOSIS

KW - Early-Onset Alzheimer's disease

KW - CHEMOTHERAPY

KW - WOMEN

KW - radiotherapy

KW - mortality

KW - cancer

KW - ASSOCIATION

KW - ONSET

KW - EPIDEMIOLOGY

UR - http://www.scopus.com/inward/record.url?scp=85082975409&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/0090c7d6-1619-32c2-a719-2cee328cb057/

U2 - 10.3390/cancers12040796

DO - 10.3390/cancers12040796

M3 - Article

AN - SCOPUS:85082975409

VL - 12

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 4

M1 - 796

ER -