For the elucidation of the substrate of destructive focuses being demonstrated in rheumatoid polyarthritis at different skeletal segments, the clinical radiological findings of 338 patients were compiled. Out of these patients 38.2% were observed over many years. The radiological findings were compared with the pathomorphological results of a typical rheumatoid soft tissue granuloma and with the results of the radiological pathomorphological examination of the whole bone joint apparatus of 5 deceased patients of the same group of disease. The destructive focuses were demonstrated to represent rheumatoid bone granulomas. New granulomas have a necrotic core sometimes with fragments of necrotic bone structures surrounded by a cellular border; later on granulomas seal off and are transformed into finely fibred connective tissue fields in the area of which new inflammatory focuses may develop. Sometimes a complete regression of the granulomas with regeneration of bone tissue is observed. Due to the absence of a perifocal exudation intraossal granulomas cannot be demonstrated clinically. Radiologically stated granulomas point to the degree of allergic response of bone tissue.