Retromer in synaptic function and pathology

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Retromer in synaptic function and pathology. / Brodin, Lennart; Шупляков, Олег Викторович.

в: Frontiers in Synaptic Neuroscience, Том 10, № 37, 24.10.2018.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{646818e1bba248bf993ffc5349edf60d,

title = "Retromer in synaptic function and pathology",

abstract = "The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including Alzheimer´s and Parkinson´s diseases. As these disorders affect synapses it is of key importance to clarify the function of retromer-dependent protein trafficking pathways in pre- and postsynaptic compartments. Here we discuss recent insights into the roles of retromer in the trafficking of synaptic vesicle proteins, neurotransmitter receptors, and other synaptic proteins. We also consider evidence that implies synapses as sites of early pathology in neurodegenerative disorders, pointing to a possible role of synaptic retromer dysfunction in the initiation of disease.",

keywords = "synapse, retorter, vesicle trafficking",

author = "Lennart Brodin and Шупляков, {Олег Викторович}",

year = "2018",

month = oct,

day = "24",

doi = "10.3389/fnsyn.2018.00037",

language = "English",

volume = "10",

journal = "Frontiers in Synaptic Neuroscience",

issn = "1663-3563",

publisher = "Frontiers Media S.A.",

number = "37",

}

RIS

TY - JOUR

T1 - Retromer in synaptic function and pathology

AU - Brodin, Lennart

AU - Шупляков, Олег Викторович

PY - 2018/10/24

Y1 - 2018/10/24

N2 - The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including Alzheimer´s and Parkinson´s diseases. As these disorders affect synapses it is of key importance to clarify the function of retromer-dependent protein trafficking pathways in pre- and postsynaptic compartments. Here we discuss recent insights into the roles of retromer in the trafficking of synaptic vesicle proteins, neurotransmitter receptors, and other synaptic proteins. We also consider evidence that implies synapses as sites of early pathology in neurodegenerative disorders, pointing to a possible role of synaptic retromer dysfunction in the initiation of disease.

AB - The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including Alzheimer´s and Parkinson´s diseases. As these disorders affect synapses it is of key importance to clarify the function of retromer-dependent protein trafficking pathways in pre- and postsynaptic compartments. Here we discuss recent insights into the roles of retromer in the trafficking of synaptic vesicle proteins, neurotransmitter receptors, and other synaptic proteins. We also consider evidence that implies synapses as sites of early pathology in neurodegenerative disorders, pointing to a possible role of synaptic retromer dysfunction in the initiation of disease.

KW - synapse

KW - retorter

KW - vesicle trafficking

UR - https://www.frontiersin.org/article/10.3389/fnsyn.2018.00037/full

UR - http://www.mendeley.com/research/retromer-synaptic-function-pathology

U2 - 10.3389/fnsyn.2018.00037

DO - 10.3389/fnsyn.2018.00037

M3 - Article

VL - 10

JO - Frontiers in Synaptic Neuroscience

JF - Frontiers in Synaptic Neuroscience

SN - 1663-3563

IS - 37

ER -

ID: 32845943

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