Restriction analysis of genome composition of live influenza vaccine › Научные исследования в СПбГУ

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Restriction analysis of genome composition of live influenza vaccine. / Kiseleva, I. V.; Larionova, N. V.; Teley, L. C.P.; Rudenko, L. G.

в: Voprosy Virusologii, Том 56, № 3, 2011, стр. 28-32.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Kiseleva, IV, Larionova, NV, Teley, LCP & Rudenko, LG 2011, 'Restriction analysis of genome composition of live influenza vaccine', Voprosy Virusologii, Том. 56, № 3, стр. 28-32.

APA

Kiseleva, I. V., Larionova, N. V., Teley, L. C. P., & Rudenko, L. G. (2011). Restriction analysis of genome composition of live influenza vaccine. Voprosy Virusologii, 56(3), 28-32.

Vancouver

Kiseleva IV, Larionova NV, Teley LCP, Rudenko LG. Restriction analysis of genome composition of live influenza vaccine. Voprosy Virusologii. 2011;56(3):28-32.

Author

Kiseleva, I. V. ; Larionova, N. V. ; Teley, L. C.P. ; Rudenko, L. G. / Restriction analysis of genome composition of live influenza vaccine. в: Voprosy Virusologii. 2011 ; Том 56, № 3. стр. 28-32.

BibTeX

@article{a95269698be44d03a98b59d8cbc211c0,

title = "Restriction analysis of genome composition of live influenza vaccine",

abstract = "Live attenuated cold-adapted influenza vaccine (LIV) has been used In Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on Influenza A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (art), respectively. The MDVs are used to generate attenuated reassortant vaccine viruses containing the surface antigens of current wild type (wt) influenza A (H1N1) and A (H3N2) viruses and wt influenza B virus. The cal tslatt phenotype of these viruses limits replication In the upper respiratory tract. Reassortment typically yields numerous viruses with different genome constellations, rapid screening is needed to select proper vaccine viruses. In this study, screening of reassortant vaccine strains for live attenuated influenza vaccine generated from currently circulating influenza A and B viruses by RFLP assay is described.",

keywords = "Influenza viruses, Reassortant vaccine strains, RFLP assay",

author = "Kiseleva, {I. V.} and Larionova, {N. V.} and Teley, {L. C.P.} and Rudenko, {L. G.}",

year = "2011",

language = "English",

volume = "56",

pages = "28--32",

journal = "Вопросы вирусологии",

issn = "0507-4088",

publisher = "Медицина",

number = "3",

}

RIS

TY - JOUR

T1 - Restriction analysis of genome composition of live influenza vaccine

AU - Kiseleva, I. V.

AU - Larionova, N. V.

AU - Teley, L. C.P.

AU - Rudenko, L. G.

PY - 2011

Y1 - 2011

N2 - Live attenuated cold-adapted influenza vaccine (LIV) has been used In Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on Influenza A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (art), respectively. The MDVs are used to generate attenuated reassortant vaccine viruses containing the surface antigens of current wild type (wt) influenza A (H1N1) and A (H3N2) viruses and wt influenza B virus. The cal tslatt phenotype of these viruses limits replication In the upper respiratory tract. Reassortment typically yields numerous viruses with different genome constellations, rapid screening is needed to select proper vaccine viruses. In this study, screening of reassortant vaccine strains for live attenuated influenza vaccine generated from currently circulating influenza A and B viruses by RFLP assay is described.

AB - Live attenuated cold-adapted influenza vaccine (LIV) has been used In Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on Influenza A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (art), respectively. The MDVs are used to generate attenuated reassortant vaccine viruses containing the surface antigens of current wild type (wt) influenza A (H1N1) and A (H3N2) viruses and wt influenza B virus. The cal tslatt phenotype of these viruses limits replication In the upper respiratory tract. Reassortment typically yields numerous viruses with different genome constellations, rapid screening is needed to select proper vaccine viruses. In this study, screening of reassortant vaccine strains for live attenuated influenza vaccine generated from currently circulating influenza A and B viruses by RFLP assay is described.

KW - Influenza viruses

KW - Reassortant vaccine strains

KW - RFLP assay

UR - http://www.scopus.com/inward/record.url?scp=79959700238&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79959700238

VL - 56

SP - 28

EP - 32

JO - Вопросы вирусологии

JF - Вопросы вирусологии

SN - 0507-4088

IS - 3

ER -

ID: 75088522