Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Regulatory mechanisms for apoptosis in placental tissue during normal pregnancy and gestosis-complicated pregnancy. / Sokolov, D. I.; Kolobov, A. V.; Lesnichija, M. V.; Kostiouchek, I. N.; Stepanova, O. I.; Kvetnoy, I. M.; Selkov, S. A.
в: Bulletin of Experimental Biology and Medicine, Том 148, № 5, 01.11.2009, стр. 766-770.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Regulatory mechanisms for apoptosis in placental tissue during normal pregnancy and gestosis-complicated pregnancy
AU - Sokolov, D. I.
AU - Kolobov, A. V.
AU - Lesnichija, M. V.
AU - Kostiouchek, I. N.
AU - Stepanova, O. I.
AU - Kvetnoy, I. M.
AU - Selkov, S. A.
PY - 2009/11/1
Y1 - 2009/11/1
N2 - The localization of apoptosis and expression of proapoptotic and antiapoptotic factors by the placental tissue were compared during normal pregnancy and gestosis-complicated pregnancy. The degree of apoptosis did not differ in the third trimester of normal pregnancy and gestosis-complicated pregnancy. Increased expression of Fas, caspase-8, and caspase-3 in placental tissue during normal pregnancy was shown to contribute to the suppression of angiogenesis and growth of placental tissue. No differences were found in the expression of FasL (CD95L), caspase-2, caspase-9, and Mcl-1 by placental cells during normal pregnancy and gestosis-complicated pregnancy. Increased expression of TRAIL by trophoblast cells is a protective mechanism from apoptotic signals of maternal cytotoxic lymphocytes and NK cells during gestosis.
AB - The localization of apoptosis and expression of proapoptotic and antiapoptotic factors by the placental tissue were compared during normal pregnancy and gestosis-complicated pregnancy. The degree of apoptosis did not differ in the third trimester of normal pregnancy and gestosis-complicated pregnancy. Increased expression of Fas, caspase-8, and caspase-3 in placental tissue during normal pregnancy was shown to contribute to the suppression of angiogenesis and growth of placental tissue. No differences were found in the expression of FasL (CD95L), caspase-2, caspase-9, and Mcl-1 by placental cells during normal pregnancy and gestosis-complicated pregnancy. Increased expression of TRAIL by trophoblast cells is a protective mechanism from apoptotic signals of maternal cytotoxic lymphocytes and NK cells during gestosis.
KW - Apoptosis
KW - Caspase
KW - CD95
KW - CD95L
KW - Mcl-1
KW - Placenta
KW - TRAIL
UR - http://www.scopus.com/inward/record.url?scp=77952032732&partnerID=8YFLogxK
U2 - 10.1007/s10517-010-0812-8
DO - 10.1007/s10517-010-0812-8
M3 - Article
C2 - 20396788
AN - SCOPUS:77952032732
VL - 148
SP - 766
EP - 770
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 5
ER -
ID: 48928120