Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae)

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Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae) : a dose-dependent effect of ecdysteroids. / Gordya, N. A.; Nesin, A. P.; Simonenko, N. P.; Chernysh, S. I.

в: Journal of Evolutionary Biochemistry and Physiology, Том 52, № 4, 01.07.2016, стр. 292-298.

Результаты исследований: Научные публикации в периодических изданиях › статья

Author

Gordya, N. A. ; Nesin, A. P. ; Simonenko, N. P. ; Chernysh, S. I. / Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae) : a dose-dependent effect of ecdysteroids. в: Journal of Evolutionary Biochemistry and Physiology. 2016 ; Том 52, № 4. стр. 292-298.

BibTeX

@article{3bdf04e1102343e28e92c8cec3b0d028,

title = "Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae): a dose-dependent effect of ecdysteroids",

abstract = "Ecdysteroids are multifunctional hormones regulating virtually all morphogenetic events in insects. Their role in stress and immune response regulation is not well researched. Here we study the effect of 20-hydroxyecdysone on antimicrobial peptide synthesis in the larvae of Calliphora vicina. An inverse correlation was observed between the 20-hydroxyecdysone titer and antimicrobial peptide concentration in the hemolymph of na{\"i}ve and bacteria challenged maggots. High and low doses of 20-hydroxyecdysone, injected simultaneously with bacterial cells, had an opposite effect on antimicrobial peptide synthesis in the diapausing larvae. Morphogenetically effective doses of 20-hydroxyecdysone demonstrated immunosuppressive activity. A low dose of 20-hydroxyecdysone, on the contrary, moderately stimulated antimicrobial peptide synthesis. The data suggest that ecdysteroids are directly involved in the regulation of the immune system activity and that the final effect is dose-dependant.",

keywords = "20-hydroxyecdysone, antimicrobial peptides, Calliphora, ecdysteroids, insect immunity",

author = "Gordya, {N. A.} and Nesin, {A. P.} and Simonenko, {N. P.} and Chernysh, {S. I.}",

year = "2016",

month = jul,

day = "1",

doi = "10.1134/S0022093016040037",

language = "English",

volume = "52",

pages = "292--298",

journal = "Journal of Evolutionary Biochemistry and Physiology",

issn = "0022-0930",

publisher = "Pleiades Publishing",

number = "4",

}

RIS

TY - JOUR

T1 - Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae)

T2 - a dose-dependent effect of ecdysteroids

AU - Gordya, N. A.

AU - Nesin, A. P.

AU - Simonenko, N. P.

AU - Chernysh, S. I.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Ecdysteroids are multifunctional hormones regulating virtually all morphogenetic events in insects. Their role in stress and immune response regulation is not well researched. Here we study the effect of 20-hydroxyecdysone on antimicrobial peptide synthesis in the larvae of Calliphora vicina. An inverse correlation was observed between the 20-hydroxyecdysone titer and antimicrobial peptide concentration in the hemolymph of naïve and bacteria challenged maggots. High and low doses of 20-hydroxyecdysone, injected simultaneously with bacterial cells, had an opposite effect on antimicrobial peptide synthesis in the diapausing larvae. Morphogenetically effective doses of 20-hydroxyecdysone demonstrated immunosuppressive activity. A low dose of 20-hydroxyecdysone, on the contrary, moderately stimulated antimicrobial peptide synthesis. The data suggest that ecdysteroids are directly involved in the regulation of the immune system activity and that the final effect is dose-dependant.

AB - Ecdysteroids are multifunctional hormones regulating virtually all morphogenetic events in insects. Their role in stress and immune response regulation is not well researched. Here we study the effect of 20-hydroxyecdysone on antimicrobial peptide synthesis in the larvae of Calliphora vicina. An inverse correlation was observed between the 20-hydroxyecdysone titer and antimicrobial peptide concentration in the hemolymph of naïve and bacteria challenged maggots. High and low doses of 20-hydroxyecdysone, injected simultaneously with bacterial cells, had an opposite effect on antimicrobial peptide synthesis in the diapausing larvae. Morphogenetically effective doses of 20-hydroxyecdysone demonstrated immunosuppressive activity. A low dose of 20-hydroxyecdysone, on the contrary, moderately stimulated antimicrobial peptide synthesis. The data suggest that ecdysteroids are directly involved in the regulation of the immune system activity and that the final effect is dose-dependant.

KW - 20-hydroxyecdysone

KW - antimicrobial peptides

KW - Calliphora

KW - ecdysteroids

KW - insect immunity

UR - http://www.scopus.com/inward/record.url?scp=84989283980&partnerID=8YFLogxK

U2 - 10.1134/S0022093016040037

DO - 10.1134/S0022093016040037

M3 - Article

AN - SCOPUS:84989283980

VL - 52

SP - 292

EP - 298

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 4

ER -

ID: 36594577