The paper presents the findings into regional imbalances in quality-of-life indicators. The authors grouped the indicators based on statistical data from the National Set of SDG Indicators collection. The basic approaches to characterizing the quality of life was reviewed. Sampling of indicators was specified. A focus on sustainable development parameters was grounded. Based on 10 indicators, the regions-entities of the North-Western Federal District of the Russian Federation were scored. The indicators were grouped as follows: income component, health component, education component, economic development component. The selected statistical data was translated into relative values, in relation to the average Russian values to obtain objective data on current imbalances in achieving the overall development potential. The findings can be used as guidelines for improving regional sustainable development programs. In particular, the Pskov region, the Nenets Autonomous Okrug, the Republic of Karelia, which received the minimum scores, can be recommended, as soon as possible, to expand the potential for economic growth, address high income differentiation of the population, an existing lag in public health and education from the all-Russian data. The presented original assessment tools will be further tested on data from other regions of the Russian Federation. A follow-up monitoring of indicators is planned to identify the trends in the target entities.