Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Receptor-ligand interactions : Advanced biomedical applications. / Guryanov, Ivan; Fiorucci, Stefano; Tennikova, Tatiana.
в: Materials Science and Engineering C, Том 68, 01.11.2016, стр. 890-903.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Receptor-ligand interactions
T2 - Advanced biomedical applications
AU - Guryanov, Ivan
AU - Fiorucci, Stefano
AU - Tennikova, Tatiana
N1 - Publisher Copyright: © 2016 Elsevier B.V.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Receptor-ligand interactions (RLIs) are at the base of all biological events occurring in living cells. The understanding of interactions between complementary macromolecules in biological systems represents a high-priority research area in bionanotechnology to design the artificial systems mimicking natural processes. This review summarizes and analyzes RLIs in some cutting-edge biomedical fields, in particular, for the preparation of novel stationary phases to separate complex biological mixtures in medical diagnostics, for the design of ultrasensitive biosensors for identification of biomarkers of various diseases at early stages, as well as in the development of innovative biomaterials and approaches for regenerative medicine. All these biotechnological fields are closely related, because their success depends on a proper choice, combination and spatial disposition of the single components of ligand-receptor pairs on the surface of appropriately designed support.
AB - Receptor-ligand interactions (RLIs) are at the base of all biological events occurring in living cells. The understanding of interactions between complementary macromolecules in biological systems represents a high-priority research area in bionanotechnology to design the artificial systems mimicking natural processes. This review summarizes and analyzes RLIs in some cutting-edge biomedical fields, in particular, for the preparation of novel stationary phases to separate complex biological mixtures in medical diagnostics, for the design of ultrasensitive biosensors for identification of biomarkers of various diseases at early stages, as well as in the development of innovative biomaterials and approaches for regenerative medicine. All these biotechnological fields are closely related, because their success depends on a proper choice, combination and spatial disposition of the single components of ligand-receptor pairs on the surface of appropriately designed support.
KW - Affinity chromatography
KW - Biosensor
KW - Ligand
KW - Receptor
KW - Regenerative medicine
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84989924508&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2016.07.072
DO - 10.1016/j.msec.2016.07.072
M3 - Review article
C2 - 27524092
VL - 68
SP - 890
EP - 903
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -
ID: 7952232