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Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. / Afanasenkau, Dzmitry; Kalinina, Daria; Lyakhovetskii, Vsevolod; Tondera, Christoph; Gorsky, Oleg; Moosavi, Seyyed; Pavlova, Natalia; Merkulyeva, Natalia; Kalueff, Allan V.; Minev, Ivan R.; Musienko, Pavel.

в: Nature Biomedical Engineering, Том 4, № 10, 01.10.2020, стр. 1010-1022.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Afanasenkau, D, Kalinina, D, Lyakhovetskii, V, Tondera, C, Gorsky, O, Moosavi, S, Pavlova, N, Merkulyeva, N, Kalueff, AV, Minev, IR & Musienko, P 2020, 'Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces', Nature Biomedical Engineering, Том. 4, № 10, стр. 1010-1022. https://doi.org/10.1038/s41551-020-00615-7

APA

Afanasenkau, D., Kalinina, D., Lyakhovetskii, V., Tondera, C., Gorsky, O., Moosavi, S., Pavlova, N., Merkulyeva, N., Kalueff, A. V., Minev, I. R., & Musienko, P. (2020). Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. Nature Biomedical Engineering, 4(10), 1010-1022. https://doi.org/10.1038/s41551-020-00615-7

Vancouver

Afanasenkau D, Kalinina D, Lyakhovetskii V, Tondera C, Gorsky O, Moosavi S и пр. Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. Nature Biomedical Engineering. 2020 Окт. 1;4(10):1010-1022. https://doi.org/10.1038/s41551-020-00615-7

Author

Afanasenkau, Dzmitry ; Kalinina, Daria ; Lyakhovetskii, Vsevolod ; Tondera, Christoph ; Gorsky, Oleg ; Moosavi, Seyyed ; Pavlova, Natalia ; Merkulyeva, Natalia ; Kalueff, Allan V. ; Minev, Ivan R. ; Musienko, Pavel. / Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. в: Nature Biomedical Engineering. 2020 ; Том 4, № 10. стр. 1010-1022.

BibTeX

@article{470d0d636f0542849f379896ba733c7f,
title = "Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces",
abstract = "Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications.",
keywords = "SPINAL-CORD, DURA-MATER, STIMULATION, DECEREBRATE, LOCOMOTION, MICROGLIA, BALANCE, BLADDER, SYSTEM, GAIT",
author = "Dzmitry Afanasenkau and Daria Kalinina and Vsevolod Lyakhovetskii and Christoph Tondera and Oleg Gorsky and Seyyed Moosavi and Natalia Pavlova and Natalia Merkulyeva and Kalueff, {Allan V.} and Minev, {Ivan R.} and Pavel Musienko",
note = "Funding Information: We acknowledge funding from the following sources: the European Research Council (804005; IntegraBrain), Saint-Petersburg State University (project 51134206; funding to O.G. and N.M. for animal facility and biocompatibility studies, and validation of the implants on in vivo models), Technische Universit{\"a}t Dresden, the Russian Foundation for Basic Research (grants 20-015-00568-a (for the urodynamic study) and 18-33-20062-mol_a_ved (for developing the optimal electrode array configuration)), Deutsche Forschungsgemeinschaft (MI 2117/1-1) and the Volkswagen Foundation (Freigeist 91 690). We thank D. E. Korzhevskiy (immunohistochemistry), Y. I. Sysoev (zebrafish model), A. V. Goriainova (functional tests) and T. Kurth (electron microscopy) for help and expertise. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = oct,
day = "1",
doi = "10.1038/s41551-020-00615-7",
language = "English",
volume = "4",
pages = "1010--1022",
journal = "Nature Biomedical Engineering",
issn = "2157-846X",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces

AU - Afanasenkau, Dzmitry

AU - Kalinina, Daria

AU - Lyakhovetskii, Vsevolod

AU - Tondera, Christoph

AU - Gorsky, Oleg

AU - Moosavi, Seyyed

AU - Pavlova, Natalia

AU - Merkulyeva, Natalia

AU - Kalueff, Allan V.

AU - Minev, Ivan R.

AU - Musienko, Pavel

N1 - Funding Information: We acknowledge funding from the following sources: the European Research Council (804005; IntegraBrain), Saint-Petersburg State University (project 51134206; funding to O.G. and N.M. for animal facility and biocompatibility studies, and validation of the implants on in vivo models), Technische Universität Dresden, the Russian Foundation for Basic Research (grants 20-015-00568-a (for the urodynamic study) and 18-33-20062-mol_a_ved (for developing the optimal electrode array configuration)), Deutsche Forschungsgemeinschaft (MI 2117/1-1) and the Volkswagen Foundation (Freigeist 91 690). We thank D. E. Korzhevskiy (immunohistochemistry), Y. I. Sysoev (zebrafish model), A. V. Goriainova (functional tests) and T. Kurth (electron microscopy) for help and expertise. Publisher Copyright: © 2020, The Author(s), under exclusive licence to Springer Nature Limited. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications.

AB - Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications.

KW - SPINAL-CORD

KW - DURA-MATER

KW - STIMULATION

KW - DECEREBRATE

KW - LOCOMOTION

KW - MICROGLIA

KW - BALANCE

KW - BLADDER

KW - SYSTEM

KW - GAIT

UR - http://www.scopus.com/inward/record.url?scp=85091197760&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/72007942-a78d-38b8-b9b3-287d5d8af55e/

U2 - 10.1038/s41551-020-00615-7

DO - 10.1038/s41551-020-00615-7

M3 - Article

AN - SCOPUS:85091197760

VL - 4

SP - 1010

EP - 1022

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

SN - 2157-846X

IS - 10

ER -

ID: 70098456