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Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms. / Burianova, Valeria; Kalinin, Stanislav; Supuran, Claudiu T.; Krasavin, Mikhail.

в: European Journal of Medicinal Chemistry, Том 213, 113046, 05.03.2021.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Burianova, V, Kalinin, S, Supuran, CT & Krasavin, M 2021, 'Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms', European Journal of Medicinal Chemistry, Том. 213, 113046. https://doi.org/10.1016/j.ejmech.2020.113046

APA

Burianova, V., Kalinin, S., Supuran, C. T., & Krasavin, M. (2021). Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms. European Journal of Medicinal Chemistry, 213, [113046]. https://doi.org/10.1016/j.ejmech.2020.113046

Vancouver

Burianova V, Kalinin S, Supuran CT, Krasavin M. Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms. European Journal of Medicinal Chemistry. 2021 Март 5;213. 113046. https://doi.org/10.1016/j.ejmech.2020.113046

Author

Burianova, Valeria ; Kalinin, Stanislav ; Supuran, Claudiu T. ; Krasavin, Mikhail. / Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms. в: European Journal of Medicinal Chemistry. 2021 ; Том 213.

BibTeX

@article{9595619de6814cc194a246b45b565815,
title = "Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms",
abstract = "The tumour-associated, cell membrane-bound isoforms IX and XII of human carbonic anhydrase (CA, EC 4.2.1.1) are overexpressed in cancer cells contributing to the hypoxic tumour pH/metabolism regulating machinery and as thus, can serve as markers of malignant neoplastic tissue. Inhibitors of CAs can be employed both for the treatment of hypoxic tumours and in the design of radiotracers for positron emission tomography and imaging of such cancers. The present review provides a comprehensive summary of the progress achieved to-date in the field of developing PET-tracers based on monoclonal antibodies, biomolecules, and small-molecule ligands of CA IX and XII.",
keywords = "Hypoxic tumour markers, Membrane-bound carbonic anhydrase isoforms, Monoclonal antibodies, Positron emission tomography, Positron-emitting radionuclides, Small-molecule inhibitors",
author = "Valeria Burianova and Stanislav Kalinin and Supuran, {Claudiu T.} and Mikhail Krasavin",
note = "Funding Information: This work was supported by the Russian Federation Government Megagrant 14.W03.031.0025. Publisher Copyright: {\textcopyright} 2020 Elsevier Masson SAS Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "5",
doi = "10.1016/j.ejmech.2020.113046",
language = "English",
volume = "213",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Radiotracers for positron emission tomography (PET) targeting tumour-associated carbonic anhydrase isoforms

AU - Burianova, Valeria

AU - Kalinin, Stanislav

AU - Supuran, Claudiu T.

AU - Krasavin, Mikhail

N1 - Funding Information: This work was supported by the Russian Federation Government Megagrant 14.W03.031.0025. Publisher Copyright: © 2020 Elsevier Masson SAS Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/3/5

Y1 - 2021/3/5

N2 - The tumour-associated, cell membrane-bound isoforms IX and XII of human carbonic anhydrase (CA, EC 4.2.1.1) are overexpressed in cancer cells contributing to the hypoxic tumour pH/metabolism regulating machinery and as thus, can serve as markers of malignant neoplastic tissue. Inhibitors of CAs can be employed both for the treatment of hypoxic tumours and in the design of radiotracers for positron emission tomography and imaging of such cancers. The present review provides a comprehensive summary of the progress achieved to-date in the field of developing PET-tracers based on monoclonal antibodies, biomolecules, and small-molecule ligands of CA IX and XII.

AB - The tumour-associated, cell membrane-bound isoforms IX and XII of human carbonic anhydrase (CA, EC 4.2.1.1) are overexpressed in cancer cells contributing to the hypoxic tumour pH/metabolism regulating machinery and as thus, can serve as markers of malignant neoplastic tissue. Inhibitors of CAs can be employed both for the treatment of hypoxic tumours and in the design of radiotracers for positron emission tomography and imaging of such cancers. The present review provides a comprehensive summary of the progress achieved to-date in the field of developing PET-tracers based on monoclonal antibodies, biomolecules, and small-molecule ligands of CA IX and XII.

KW - Hypoxic tumour markers

KW - Membrane-bound carbonic anhydrase isoforms

KW - Monoclonal antibodies

KW - Positron emission tomography

KW - Positron-emitting radionuclides

KW - Small-molecule inhibitors

UR - http://www.scopus.com/inward/record.url?scp=85097742805&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/3435ea89-3756-368e-8ed2-1c7d02a73474/

U2 - 10.1016/j.ejmech.2020.113046

DO - 10.1016/j.ejmech.2020.113046

M3 - Review article

AN - SCOPUS:85097742805

VL - 213

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

M1 - 113046

ER -

ID: 72053233