TY - JOUR

T1 - Publication-based analysis of miR-210 dependent biomarkers of pre-eclampsia.

AU - Tkachenko, Alexander

AU - Illarionov, Roman

AU - Vashukova, Elena

AU - Glotov, Andrei

PY - 2020

Y1 - 2020

N2 - MicroRNAs (miRNAs) are potential biomarkers of most pregnancy complications. In recent years, miR-210 has been shown as one of the main biomarkers, detected at different stages of pregnancy and associated with various diseases, including pre-eclampsia (PE). However, miR-210 is not reported as a marker of PE in about half of the studies. We filtered available published RNA-seq data and miRNAs associated with PE, including or excluding miR-210, obtained from the PregMiR database. For further analysis we only considered miRNAs appearing in at least four different studies. We observed that miR-152, miR-1 and miR-193b were only detected in studies with a changed miR-210 level, whereas miR-27a, miR-29a, miR-130a and miR-519b were detected in studies without miRNA-210 differential expression. Common biomarkers of PE are miR-182, miR-126, miR-155, miR-181a, miR-18a, miR-195, miR-21, miR-223, miR-335, miR-517c, miR-518b, miR-518e and let-7f. Based on the obtained data and taking into account the direction of different

AB - MicroRNAs (miRNAs) are potential biomarkers of most pregnancy complications. In recent years, miR-210 has been shown as one of the main biomarkers, detected at different stages of pregnancy and associated with various diseases, including pre-eclampsia (PE). However, miR-210 is not reported as a marker of PE in about half of the studies. We filtered available published RNA-seq data and miRNAs associated with PE, including or excluding miR-210, obtained from the PregMiR database. For further analysis we only considered miRNAs appearing in at least four different studies. We observed that miR-152, miR-1 and miR-193b were only detected in studies with a changed miR-210 level, whereas miR-27a, miR-29a, miR-130a and miR-519b were detected in studies without miRNA-210 differential expression. Common biomarkers of PE are miR-182, miR-126, miR-155, miR-181a, miR-18a, miR-195, miR-21, miR-223, miR-335, miR-517c, miR-518b, miR-518e and let-7f. Based on the obtained data and taking into account the direction of different

KW - bioinformatics analysis

KW - miR-210

KW - miRNA

KW - pre-eclampsia

KW - pregnancy complications

KW - bioinformatics analysis

KW - miR-210

KW - miRNA

KW - pre-eclampsia

KW - pregnancy complications

M3 - Article

VL - 65

SP - 163

EP - 177

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

IS - 2

ER -