TY - JOUR

T1 - Prospects for the use of autologous platelet-rich plasma in patients with recurrent implantation failure

AU - Obidniak, Diana M.

AU - Gzgzyan , Alexander M.

AU - Niauri, Dariko A.

AU - Chkhaidze, Ia Z.

PY - 2017

Y1 - 2017

N2 - Objective — to identify if intrauterine perfusion with autologous platelet-rich plasma enhances frozen-thawed embryo transfer effectiveness in patients with RIF Material and methods. Interventional open-label study. After signing informed consent 90 women with RIF were involved. The two groups of patients were formed on the basis of blocked randomization with randomly selected block sizes: 1) study group №1 (n=45): intrauterine perfusion with autologous PRP using insemination catheter on 10/11 day of menstrual cycle; 2) control group: no intervention (n=45). Results. The endometrial thickness at the day of embryotransfer was higher in the study group comparing to the control group (χ=47.78; p<0.001). The significantly higher clinical pregnancy was also noted in the study group (53.3% vs 26.6%) (χ=6.667; OR= 3.14, 95% CI 1.30—7.59; p<0.01). The implantation rate in the study group reached 40.5% that exceeded the control group data (20.9%). There was no statistically significant difference between groups when comparing the miscarriage rate (χwith Yats correction=0.225, OR = 1.0, 95% Cl 0.15—6.42; p>0.05). No adverse event was noted. Conclusion. The intrauterine perfusion with PRP is perceived to have high therapeutic safety, good tolerability and reproducibility. The intrauterine perfusion with aPRP seems to be expedient in patients with RIF on purpose to improve outcomes of frozen-thawed embryo transfer.

AB - Objective — to identify if intrauterine perfusion with autologous platelet-rich plasma enhances frozen-thawed embryo transfer effectiveness in patients with RIF Material and methods. Interventional open-label study. After signing informed consent 90 women with RIF were involved. The two groups of patients were formed on the basis of blocked randomization with randomly selected block sizes: 1) study group №1 (n=45): intrauterine perfusion with autologous PRP using insemination catheter on 10/11 day of menstrual cycle; 2) control group: no intervention (n=45). Results. The endometrial thickness at the day of embryotransfer was higher in the study group comparing to the control group (χ=47.78; p<0.001). The significantly higher clinical pregnancy was also noted in the study group (53.3% vs 26.6%) (χ=6.667; OR= 3.14, 95% CI 1.30—7.59; p<0.01). The implantation rate in the study group reached 40.5% that exceeded the control group data (20.9%). There was no statistically significant difference between groups when comparing the miscarriage rate (χwith Yats correction=0.225, OR = 1.0, 95% Cl 0.15—6.42; p>0.05). No adverse event was noted. Conclusion. The intrauterine perfusion with PRP is perceived to have high therapeutic safety, good tolerability and reproducibility. The intrauterine perfusion with aPRP seems to be expedient in patients with RIF on purpose to improve outcomes of frozen-thawed embryo transfer.

U2 - DOI:10.17116/repro201723584-88

DO - DOI:10.17116/repro201723584-88

M3 - Article

VL - 23

SP - 84

JO - ПРОБЛЕМЫ РЕПРОДУКЦИИ

JF - ПРОБЛЕМЫ РЕПРОДУКЦИИ

SN - 1025-7217

IS - 5

ER -