Due to the increasing prevalence of depression, it is necessary to improve medical care to manage the disease. The problems of regulation of medical care quality are analyzed in the article. It is established that the problems are connected both with the general economic condition of Russia, and with the problems in regulation of activity. The second group of problems includes the absence of approved clinical recommendations, mixing of different nosologies in the Standards and Criteria of quality, incomplete set of examinations necessary for patients with depression. Further economic development and approval of the Clinical Guidelines should improve the quality and availability of care for depressed patients.