TY - JOUR

T1 - Prions and the concept of polyprionic inheritance

AU - Galkin, Alexey P.

N1 - Publisher Copyright: © 2017, Springer-Verlag Berlin Heidelberg.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Discovery of prions—proteins that are able to convert between structurally distinct states, of which one or more is transmissible, led to the concept of “protein-based inheritance”. According to this concept, the formation of prion fibrils causes DNA-independent heritable traits in microorganisms. Recently, we described a new and unusual type of prion inheritance. We showed that the yeast prions [PIN+] and [SWI+], like classical genes, demonstrate complementary interaction that causes a phenotypic change in yeast cells. Here, we discuss the possible mechanisms of such polyprionic inheritance and the perspectives in the identification of prions in various organisms using universal proteomic approaches.

AB - Discovery of prions—proteins that are able to convert between structurally distinct states, of which one or more is transmissible, led to the concept of “protein-based inheritance”. According to this concept, the formation of prion fibrils causes DNA-independent heritable traits in microorganisms. Recently, we described a new and unusual type of prion inheritance. We showed that the yeast prions [PIN+] and [SWI+], like classical genes, demonstrate complementary interaction that causes a phenotypic change in yeast cells. Here, we discuss the possible mechanisms of such polyprionic inheritance and the perspectives in the identification of prions in various organisms using universal proteomic approaches.

KW - Amyloid

KW - Polyprionic inheritance

KW - Prion

KW - Proteomic screen

KW - Yeast

UR - http://www.scopus.com/inward/record.url?scp=85014219715&partnerID=8YFLogxK

U2 - 10.1007/s00294-017-0685-8

DO - 10.1007/s00294-017-0685-8

M3 - Review article

C2 - 28260124

AN - SCOPUS:85014219715

VL - 63

SP - 799

EP - 802

JO - Current Genetics

JF - Current Genetics

SN - 0172-8083

IS - 5

ER -