Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Prions and Non-infectious Amyloids of Mammals – Similarities and Differences. / Galkin, A. P.; Velizhanina, M. E.; Sopova, Yu V.; Shenfeld, A. A.; Zadorsky, S. P.
в: Biochemistry (Moscow), Том 83, № 10, 10.2018, стр. 1184-1195.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Prions and Non-infectious Amyloids of Mammals – Similarities and Differences
AU - Galkin, A. P.
AU - Velizhanina, M. E.
AU - Sopova, Yu V.
AU - Shenfeld, A. A.
AU - Zadorsky, S. P.
PY - 2018/10
Y1 - 2018/10
N2 - Amyloids are highly ordered aggregates of protein fibrils exhibiting cross-β structure formed by intermolecular hydrogen bonds. Pathological amyloid deposition is associated with the development of several socially significant incurable human diseases. Of particular interest are infectious amyloids, or prions, that cause several lethal neurodegenerative diseases in humans and can be transmitted from one organism to another. Because of almost complete absence of criteria for infectious and non-infectious amyloids, there is a lack of consensus, especially, in the definition of similarities and differences between prions and non-infectious amyloids. In this review, we formulated contemporary molecular-biological criteria for identification of prions and non-infectious amyloids and focused on explaining the differences between these two types of molecules.
AB - Amyloids are highly ordered aggregates of protein fibrils exhibiting cross-β structure formed by intermolecular hydrogen bonds. Pathological amyloid deposition is associated with the development of several socially significant incurable human diseases. Of particular interest are infectious amyloids, or prions, that cause several lethal neurodegenerative diseases in humans and can be transmitted from one organism to another. Because of almost complete absence of criteria for infectious and non-infectious amyloids, there is a lack of consensus, especially, in the definition of similarities and differences between prions and non-infectious amyloids. In this review, we formulated contemporary molecular-biological criteria for identification of prions and non-infectious amyloids and focused on explaining the differences between these two types of molecules.
KW - amyloids
KW - fibrils
KW - infectivity
KW - prions
KW - protein aggregates
KW - ALZHEIMERS-DISEASE
KW - FUNCTIONAL PRION
KW - SPONGIFORM ENCEPHALOPATHY
KW - X-RAY-DIFFRACTION
KW - AMYOTROPHIC-LATERAL-SCLEROSIS
KW - PATHOLOGICAL ALPHA-SYNUCLEIN
KW - LONG-TERM FACILITATION
KW - SUPEROXIDE-DISMUTASE
KW - HUNTINGTONS-DISEASE
KW - PARKINSONS-DISEASE
UR - http://www.scopus.com/inward/record.url?scp=85055024370&partnerID=8YFLogxK
UR - http://link.springer.com/10.1134/S0006297918100048
UR - http://www.mendeley.com/research/prions-noninfectious-amyloids-mammals-similarities-differences
U2 - 10.1134/S0006297918100048
DO - 10.1134/S0006297918100048
M3 - Review article
AN - SCOPUS:85055024370
VL - 83
SP - 1184
EP - 1195
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - 10
ER -
ID: 35479223