Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава/раздел › научная › Рецензирование
Presynaptic Endosomes. / Shupliakov, O.; Fernández-Chacón, R.
Encyclopedia of Neuroscience. Elsevier, 2010. стр. 975-979.Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава/раздел › научная › Рецензирование
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TY - CHAP
T1 - Presynaptic Endosomes
AU - Shupliakov, O.
AU - Fernández-Chacón, R.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Presynaptic endosomes are intracellular organelles involved in the recycling and degradation of receptors and membrane proteins. They also play a role in maintaining the pool of synaptic vesicles and in the recycling of dense-core vesicle membranes during neurotransmitter release. Although the molecular mechanisms involving presynaptic endosomes are not yet well characterized, the small GTPase Rab5, the SNARE protein Vti1ab, and the adaptor protein complex AP-3 have been identified as components of the endosomal trafficking. In addition, a 'signaling endosome' functioning parallel to the degradation pathway has been implicated in the transport of neurotrophic signals and toxins from the synapse.
AB - Presynaptic endosomes are intracellular organelles involved in the recycling and degradation of receptors and membrane proteins. They also play a role in maintaining the pool of synaptic vesicles and in the recycling of dense-core vesicle membranes during neurotransmitter release. Although the molecular mechanisms involving presynaptic endosomes are not yet well characterized, the small GTPase Rab5, the SNARE protein Vti1ab, and the adaptor protein complex AP-3 have been identified as components of the endosomal trafficking. In addition, a 'signaling endosome' functioning parallel to the degradation pathway has been implicated in the transport of neurotrophic signals and toxins from the synapse.
KW - Chemical synapse
KW - Clathrin-coated vesicles
KW - Dense-core vesicles
KW - Endocytosis
KW - Endosome
KW - Rab proteins
KW - Small synaptic vesicles
KW - Synaptic receptors
KW - Toxins
UR - http://www.scopus.com/inward/record.url?scp=84882859963&partnerID=8YFLogxK
U2 - 10.1016/B978-008045046-9.01783-6
DO - 10.1016/B978-008045046-9.01783-6
M3 - Chapter
SN - 9780080450469
SP - 975
EP - 979
BT - Encyclopedia of Neuroscience
PB - Elsevier
ER -
ID: 40829838