Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Preparation and spatial structure of methyl ether of 7 beta-methyl-D-homo-6-oxaestra-1,3,5(10),8(9)-tetraen-17a-one. / Morozkina, S. N.; Zashikhina, N. N.; Selivanov, S. I.; Shavva, A. G.
в: Russian Journal of General Chemistry, Том 84, № 9, 2014, стр. 1716-1721.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Preparation and spatial structure of methyl ether of 7 beta-methyl-D-homo-6-oxaestra-1,3,5(10),8(9)-tetraen-17a-one
AU - Morozkina, S. N.
AU - Zashikhina, N. N.
AU - Selivanov, S. I.
AU - Shavva, A. G.
PY - 2014
Y1 - 2014
N2 - Procedure of preparation of 7 beta-methyl-D-homo-6-oxa-1,3,5(10),8,(9)-estratetraen-17a-one methyl ether has been developed; the product conformation in the solution has been studied by NMR spectroscopy. Comparison of the experimental data with simulation of similar compounds docking into the ligand-binding pocket of the estrogens alpha-receptor has suggested that such steroids are promising for preparation of biologically active substances whose action would not be mediated by the estrogens receptors.
AB - Procedure of preparation of 7 beta-methyl-D-homo-6-oxa-1,3,5(10),8,(9)-estratetraen-17a-one methyl ether has been developed; the product conformation in the solution has been studied by NMR spectroscopy. Comparison of the experimental data with simulation of similar compounds docking into the ligand-binding pocket of the estrogens alpha-receptor has suggested that such steroids are promising for preparation of biologically active substances whose action would not be mediated by the estrogens receptors.
U2 - 10.1134/S1070363214090138
DO - 10.1134/S1070363214090138
M3 - Article
VL - 84
SP - 1716
EP - 1721
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 9
ER -
ID: 7065420