Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
PPARα gene variation and physical performance in Russian athletes. / Ahmetov, Ildus I.; Mozhayskaya, Irina A.; Flavell, David M.; Astratenkova, Irina V.; Komkova, Antonina I.; Lyubaeva, Ekaterina V.; Tarakin, Pavel P.; Shenkman, Boris S.; Vdovina, Anastasia B.; Netreba, Aleksei I.; Popov, Daniil V.; Vinogradova, Olga L.; Montgomery, Hugh E.; Rogozkin, Viktor A.
в: European Journal of Applied Physiology, Том 97, № 1, 01.05.2006, стр. 103-108.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - PPARα gene variation and physical performance in Russian athletes
AU - Ahmetov, Ildus I.
AU - Mozhayskaya, Irina A.
AU - Flavell, David M.
AU - Astratenkova, Irina V.
AU - Komkova, Antonina I.
AU - Lyubaeva, Ekaterina V.
AU - Tarakin, Pavel P.
AU - Shenkman, Boris S.
AU - Vdovina, Anastasia B.
AU - Netreba, Aleksei I.
AU - Popov, Daniil V.
AU - Vinogradova, Olga L.
AU - Montgomery, Hugh E.
AU - Rogozkin, Viktor A.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Peroxisome proliferator-activated receptor α (PPARα) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARα intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPARα intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P<0.0001) different compared to controls (70.0%). To examine the association between PPARα gene variant and fiber type composition, muscle biopsies from m. vastus lateralis were obtained and analyzed in 40 young men. GG homozygotes (n=25) had significantly (P=0.003) higher percentages of slow-twitch fibers (55.5±2.0 vs 38.5±2.3%) than CC homozygotes (n=4). In conclusion, PPARα intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARα genotype and muscle fiber type composition.
AB - Peroxisome proliferator-activated receptor α (PPARα) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARα intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPARα intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P<0.0001) different compared to controls (70.0%). To examine the association between PPARα gene variant and fiber type composition, muscle biopsies from m. vastus lateralis were obtained and analyzed in 40 young men. GG homozygotes (n=25) had significantly (P=0.003) higher percentages of slow-twitch fibers (55.5±2.0 vs 38.5±2.3%) than CC homozygotes (n=4). In conclusion, PPARα intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARα genotype and muscle fiber type composition.
KW - Fatty acids
KW - Muscle fiber type
KW - Physical performance
KW - Polymorphism
KW - PPARα
UR - http://www.scopus.com/inward/record.url?scp=33745436772&partnerID=8YFLogxK
U2 - 10.1007/s00421-006-0154-4
DO - 10.1007/s00421-006-0154-4
M3 - Article
C2 - 16506057
AN - SCOPUS:33745436772
VL - 97
SP - 103
EP - 108
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
SN - 1439-6319
IS - 1
ER -
ID: 42844247