Introduction. The prognostication of high-tech heart surgery outcomes is a relevant aspect in medicine. However, in this field a prognosis of psychological nature is also in evidence, such as predicting the patients’ return to work after myocardial revascularization when there are no medical contraindications for it, as well as predicting patients’ adherence to supportive treatment after revascularization. Aim: to evaluate the predictive potentials of the patients’ psychological characteristics in terms of their returning to work and adherence to treatment after bypass grafting. Methods. An interview for patients performed at different stages of treatment, which included questions on patient’s labor activities and their adherence to treatment; psychometric techniques, the Big Five Questionnaire, the SF-36 Questionnaire, the Integrative Anxiety Test (IAT), the Lazarus and Folkman Ways of Coping Questionnaire (WCQ), the Technique for Diagnosing the Types of Attitude toward the Disease (“TOBOL”) among them. 159 patients were studied in 2 stages: 1) 63 employable patients were examined regarding their return to labor activity after surgery; 2) 96 patients – regarding their adherence to medical recommendations after surgery. Results. The discriminant analysis allowed to obtain the following data. The higher the scores on the “Extroversion” scale (BIG V), on the “Social Activity” scale (SF-36) and on the “Social Protection” scale (IAT), the higher the probability of the patient returning to work (Lambda = 0.76, χ 2 = 16.67; p < 0.001). The lower the value on the “anosognosic type” (“TOBOL”) and the higher the value on the “sensitive type” (“TOBOL”) in combination with high values of the “search for social support” scale (WCQ), the higher the likelihood of the patient being adherent to treatment (Lambda = 0.62, χ 2 = 10.85; p < 0.01). Conclusion. The findings show a high significance of psychological characteristics for predicting the behavior of patients after myocardial revascularization. Further detailed study of these correlations is required, as well as consideration of implementing in the psychological support of patients at the cardiac surgery departments the results obtained.