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Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty. / Gordienko, Vasily A.; Zinoviev, Evgenii V.; Kostyakov, Denis V.; Asadulaev, Marat S.; Shabunin, Anton S.; Yudin, Vladimir E.; Smirnova, Nataliya V.; Radeeva, Anna V.; Paneiakh, Moisei B.

в: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, Том 8, № 2, 2020, стр. 185-196.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Gordienko, VA, Zinoviev, EV, Kostyakov, DV, Asadulaev, MS, Shabunin, AS, Yudin, VE, Smirnova, NV, Radeeva, AV & Paneiakh, MB 2020, 'Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty', Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, Том. 8, № 2, стр. 185-196. https://doi.org/10.17816/PTORS25751

APA

Gordienko, V. A., Zinoviev, E. V., Kostyakov, D. V., Asadulaev, M. S., Shabunin, A. S., Yudin, V. E., Smirnova, N. V., Radeeva, A. V., & Paneiakh, M. B. (2020). Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, 8(2), 185-196. https://doi.org/10.17816/PTORS25751

Vancouver

Gordienko VA, Zinoviev EV, Kostyakov DV, Asadulaev MS, Shabunin AS, Yudin VE и пр. Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2020;8(2):185-196. https://doi.org/10.17816/PTORS25751

Author

Gordienko, Vasily A. ; Zinoviev, Evgenii V. ; Kostyakov, Denis V. ; Asadulaev, Marat S. ; Shabunin, Anton S. ; Yudin, Vladimir E. ; Smirnova, Nataliya V. ; Radeeva, Anna V. ; Paneiakh, Moisei B. / Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty. в: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2020 ; Том 8, № 2. стр. 185-196.

BibTeX

@article{12a2cd8f4c7c4f218bf5302c32f7c33c,
title = "Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty",
abstract = "Background. The treatment of victims with wound defects is an urgent problem of clinical medicine that doctors of various specialties, mainly surgeons and traumatologists, must face. Regardless of the etiology of the traumatic agent, the wound process is always subjected to fundamental pathophysiological processes. Despite the advances made by medical science in the local treatment of wounds (cell technology, modern wound coverings, and others), surgical procedures remain the main methods, and the search for new techniques to optimize reparative regeneration continues. This ongoing search indicates the absence of a universal algorithm for treating such defects. This lack of a universal treatment algorithm is of particular importance for assisting victims with extensive defects, which often leads to a shortage of donor resources. Aim. The aim of this study was to increase the efficiency of microautodermoplasty due to the use of allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide. Materials and methods. This paper presents the results of an experimental study involving 50 rats. All animals were divided into groups considering the choice of the method of the local treatment. The experimental wound was modeled according to its original technique. The evaluation of the effectiveness of the analyzed methods was performed using planimetric and histological research methods, and by calculating the healing index. Results. The most effective methods for treating experimental wounds using microautodermoplasty (MADP) are wound dressings based on aliphatic copolyamide (CoPA) and adipogenic mesenchymal stem cells (AMSC). By 28 days of treatment after performing MADP + CoPA wound dressings + AMSC, it was possible to reduce the defect area by 16 times compared with the control, and the healing index was the maximum value among all methods — 12.5 units. The high regenerative potential was also confirmed by the results of the histological examination. The worst results were found in the MADP group with AMSK that did not cover the wounds with skin or wound dressing. Conclusion. The introduction of the analyzed methods into clinical practice will improve the results of treatment of patients with wound defects of various etiologies.",
keywords = "Aliphatic copolyamide, Burn, Extensive wound defects, Microautodermoplasty, Stem cells, Wound, Wound dressings",
author = "Gordienko, {Vasily A.} and Zinoviev, {Evgenii V.} and Kostyakov, {Denis V.} and Asadulaev, {Marat S.} and Shabunin, {Anton S.} and Yudin, {Vladimir E.} and Smirnova, {Nataliya V.} and Radeeva, {Anna V.} and Paneiakh, {Moisei B.}",
note = "Publisher Copyright: {\textcopyright} 2020, Eco-Vector LLC. All rights reserved.",
year = "2020",
doi = "10.17816/PTORS25751",
language = "English",
volume = "8",
pages = "185--196",
journal = "ОРТОПЕДИЯ, ТРАВМАТОЛОГИЯ И ВОССТАНОВИТЕЛЬНАЯ ХИРУРГИЯ ДЕТСКОГО ВОЗРАСТА ",
issn = "2309-3994",
publisher = "LLC Eco-Vector",
number = "2",

}

RIS

TY - JOUR

T1 - Possibilities of using allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide in microautodermoplasty

AU - Gordienko, Vasily A.

AU - Zinoviev, Evgenii V.

AU - Kostyakov, Denis V.

AU - Asadulaev, Marat S.

AU - Shabunin, Anton S.

AU - Yudin, Vladimir E.

AU - Smirnova, Nataliya V.

AU - Radeeva, Anna V.

AU - Paneiakh, Moisei B.

N1 - Publisher Copyright: © 2020, Eco-Vector LLC. All rights reserved.

PY - 2020

Y1 - 2020

N2 - Background. The treatment of victims with wound defects is an urgent problem of clinical medicine that doctors of various specialties, mainly surgeons and traumatologists, must face. Regardless of the etiology of the traumatic agent, the wound process is always subjected to fundamental pathophysiological processes. Despite the advances made by medical science in the local treatment of wounds (cell technology, modern wound coverings, and others), surgical procedures remain the main methods, and the search for new techniques to optimize reparative regeneration continues. This ongoing search indicates the absence of a universal algorithm for treating such defects. This lack of a universal treatment algorithm is of particular importance for assisting victims with extensive defects, which often leads to a shortage of donor resources. Aim. The aim of this study was to increase the efficiency of microautodermoplasty due to the use of allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide. Materials and methods. This paper presents the results of an experimental study involving 50 rats. All animals were divided into groups considering the choice of the method of the local treatment. The experimental wound was modeled according to its original technique. The evaluation of the effectiveness of the analyzed methods was performed using planimetric and histological research methods, and by calculating the healing index. Results. The most effective methods for treating experimental wounds using microautodermoplasty (MADP) are wound dressings based on aliphatic copolyamide (CoPA) and adipogenic mesenchymal stem cells (AMSC). By 28 days of treatment after performing MADP + CoPA wound dressings + AMSC, it was possible to reduce the defect area by 16 times compared with the control, and the healing index was the maximum value among all methods — 12.5 units. The high regenerative potential was also confirmed by the results of the histological examination. The worst results were found in the MADP group with AMSK that did not cover the wounds with skin or wound dressing. Conclusion. The introduction of the analyzed methods into clinical practice will improve the results of treatment of patients with wound defects of various etiologies.

AB - Background. The treatment of victims with wound defects is an urgent problem of clinical medicine that doctors of various specialties, mainly surgeons and traumatologists, must face. Regardless of the etiology of the traumatic agent, the wound process is always subjected to fundamental pathophysiological processes. Despite the advances made by medical science in the local treatment of wounds (cell technology, modern wound coverings, and others), surgical procedures remain the main methods, and the search for new techniques to optimize reparative regeneration continues. This ongoing search indicates the absence of a universal algorithm for treating such defects. This lack of a universal treatment algorithm is of particular importance for assisting victims with extensive defects, which often leads to a shortage of donor resources. Aim. The aim of this study was to increase the efficiency of microautodermoplasty due to the use of allogeneic mesenchymal stem cells and wound dressings based on aliphatic copolyamide. Materials and methods. This paper presents the results of an experimental study involving 50 rats. All animals were divided into groups considering the choice of the method of the local treatment. The experimental wound was modeled according to its original technique. The evaluation of the effectiveness of the analyzed methods was performed using planimetric and histological research methods, and by calculating the healing index. Results. The most effective methods for treating experimental wounds using microautodermoplasty (MADP) are wound dressings based on aliphatic copolyamide (CoPA) and adipogenic mesenchymal stem cells (AMSC). By 28 days of treatment after performing MADP + CoPA wound dressings + AMSC, it was possible to reduce the defect area by 16 times compared with the control, and the healing index was the maximum value among all methods — 12.5 units. The high regenerative potential was also confirmed by the results of the histological examination. The worst results were found in the MADP group with AMSK that did not cover the wounds with skin or wound dressing. Conclusion. The introduction of the analyzed methods into clinical practice will improve the results of treatment of patients with wound defects of various etiologies.

KW - Aliphatic copolyamide

KW - Burn

KW - Extensive wound defects

KW - Microautodermoplasty

KW - Stem cells

KW - Wound

KW - Wound dressings

UR - http://www.scopus.com/inward/record.url?scp=85087611551&partnerID=8YFLogxK

U2 - 10.17816/PTORS25751

DO - 10.17816/PTORS25751

M3 - Article

AN - SCOPUS:85087611551

VL - 8

SP - 185

EP - 196

JO - ОРТОПЕДИЯ, ТРАВМАТОЛОГИЯ И ВОССТАНОВИТЕЛЬНАЯ ХИРУРГИЯ ДЕТСКОГО ВОЗРАСТА

JF - ОРТОПЕДИЯ, ТРАВМАТОЛОГИЯ И ВОССТАНОВИТЕЛЬНАЯ ХИРУРГИЯ ДЕТСКОГО ВОЗРАСТА

SN - 2309-3994

IS - 2

ER -

ID: 86297920