Polyester-based microparticles of different hydrophobicity: the patterns of lipophilic drug entrapment and release

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Polyester-based microparticles of different hydrophobicity: the patterns of lipophilic drug entrapment and release. / Korzhikov, Viktor; Averianov, Ilia; Litvinchuk, Evgeniia; Tennikova, Tatiana B.

в: Journal of Microencapsulation, Том 33, № 3, 2016, стр. 199-208.

Результаты исследований: Научные публикации в периодических изданиях › статья

BibTeX

@article{40684af20afa4f31a1705bad03755ab0,

title = "Polyester-based microparticles of different hydrophobicity: the patterns of lipophilic drug entrapment and release",

abstract = "The paper is devoted to the investigation of the effect of polyester hydrophobicity and ability for crystallisation on lipophilic drug loading and release from microparticles fabricated on the base of these polymers. Poly(L-lactic acid), poly(D, L-lactic acid) and poly (lactic acid-co-glycolic acid) were synthesised by ring-opening polymerisation using stannous octoate as catalyst, while poly(caprolactone) (PCL) and poly(!- pentadecalactone) (PPDL) formation was catalysed by lipase. The particles were formed via single emulsion evaporation/diffusion method. The particles obtained were studied using SEM, XRD and DSC methods. The degradation of particles based on different polyesters, entrapment and release of a model hydrophobic drug (risperidone) were thoroughly studied. The effect of particles hydrophobicity and crystallinity on these parameters was of most interest. The drug entrapment is greater for the hydrophobic polymers. Drug release was more rapid from crystalline particles (PLLA, PCL, PPDL), than fro",

keywords = "Biodegradable particles, drug encapsulation, drug release, risperidone",

author = "Viktor Korzhikov and Ilia Averianov and Evgeniia Litvinchuk and Tennikova, {Tatiana B.}",

year = "2016",

doi = "10.3109/02652048.2016.1144818",

language = "English",

volume = "33",

pages = "199--208",

journal = "Journal of Microencapsulation",

issn = "0265-2048",

publisher = "Informa Healthcare",

number = "3",

}

RIS

TY - JOUR

T1 - Polyester-based microparticles of different hydrophobicity: the patterns of lipophilic drug entrapment and release

AU - Korzhikov, Viktor

AU - Averianov, Ilia

AU - Litvinchuk, Evgeniia

AU - Tennikova, Tatiana B.

PY - 2016

Y1 - 2016

N2 - The paper is devoted to the investigation of the effect of polyester hydrophobicity and ability for crystallisation on lipophilic drug loading and release from microparticles fabricated on the base of these polymers. Poly(L-lactic acid), poly(D, L-lactic acid) and poly (lactic acid-co-glycolic acid) were synthesised by ring-opening polymerisation using stannous octoate as catalyst, while poly(caprolactone) (PCL) and poly(!- pentadecalactone) (PPDL) formation was catalysed by lipase. The particles were formed via single emulsion evaporation/diffusion method. The particles obtained were studied using SEM, XRD and DSC methods. The degradation of particles based on different polyesters, entrapment and release of a model hydrophobic drug (risperidone) were thoroughly studied. The effect of particles hydrophobicity and crystallinity on these parameters was of most interest. The drug entrapment is greater for the hydrophobic polymers. Drug release was more rapid from crystalline particles (PLLA, PCL, PPDL), than fro

AB - The paper is devoted to the investigation of the effect of polyester hydrophobicity and ability for crystallisation on lipophilic drug loading and release from microparticles fabricated on the base of these polymers. Poly(L-lactic acid), poly(D, L-lactic acid) and poly (lactic acid-co-glycolic acid) were synthesised by ring-opening polymerisation using stannous octoate as catalyst, while poly(caprolactone) (PCL) and poly(!- pentadecalactone) (PPDL) formation was catalysed by lipase. The particles were formed via single emulsion evaporation/diffusion method. The particles obtained were studied using SEM, XRD and DSC methods. The degradation of particles based on different polyesters, entrapment and release of a model hydrophobic drug (risperidone) were thoroughly studied. The effect of particles hydrophobicity and crystallinity on these parameters was of most interest. The drug entrapment is greater for the hydrophobic polymers. Drug release was more rapid from crystalline particles (PLLA, PCL, PPDL), than fro

KW - Biodegradable particles

KW - drug encapsulation

KW - drug release

KW - risperidone

U2 - 10.3109/02652048.2016.1144818

DO - 10.3109/02652048.2016.1144818

M3 - Article

VL - 33

SP - 199

EP - 208

JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

SN - 0265-2048

IS - 3

ER -

ID: 7554847