Plasma D-Dimer Level as a Subclinical Marker of Thrombotic Risk in Elderly Patients with Atrial Fibrillation

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Plasma D-Dimer Level as a Subclinical Marker of Thrombotic Risk in Elderly Patients with Atrial Fibrillation. / Zadvorev, S. F.; Zamytskaya, A. A.; Piskunov, D. P.; Pushkin, A. S.; Yakovlev, A. A.

в: Advances in Gerontology, Том 10, № 1, 01.01.2020, стр. 73-78.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Zadvorev, S. F. ; Zamytskaya, A. A. ; Piskunov, D. P. ; Pushkin, A. S. ; Yakovlev, A. A. / Plasma D-Dimer Level as a Subclinical Marker of Thrombotic Risk in Elderly Patients with Atrial Fibrillation. в: Advances in Gerontology. 2020 ; Том 10, № 1. стр. 73-78.

BibTeX

@article{97cd14ec719f4967b5154eacd989a2d6,

title = "Plasma D-Dimer Level as a Subclinical Marker of Thrombotic Risk in Elderly Patients with Atrial Fibrillation",

abstract = "Aged patients with atrial fibrillation (AF) are at high risk of both thromboembolic and hemorrhagic complications of the disease and its treatment. A study was conducted to assess the role of the D-dimer plasma level as a marker of thrombosis in aged patients with AF having no clinical signs of active thrombosis with respect to the used treatment strategy and the quantitative thrombotic and hemorrhagic risk of AF. The results show that the D-dimer plasma levels correlate with the scores of thromboembolic and hemorrhagic risks in groups on antiplatelet agents but not anticoagulants, with the difference in D-dimer level driven by a subgroup on CHA2DS2-VASc point ≥5. A high D-dimer level was associated with in-hospital mortality and AF rhythm at the moment of blood sample collection. Therefore, the accuracy of risk prognosis for fatal complications of AF in elderly patients may be increased with the use of the laboratory markers of thrombus formation such as the D-dimer level and with the use of the obtained results as a guide to antithrombotic therapy.",

keywords = "anticoagulants, antiplatelet agents, atrial fibrillation, D-dimer",

author = "Zadvorev, {S. F.} and Zamytskaya, {A. A.} and Piskunov, {D. P.} and Pushkin, {A. S.} and Yakovlev, {A. A.}",

note = "Publisher Copyright: {\textcopyright} 2020, Pleiades Publishing, Ltd.",

year = "2020",

month = jan,

day = "1",

doi = "10.1134/S2079057020010166",

language = "English",

volume = "10",

pages = "73--78",

journal = "Advances in Gerontology",

issn = "2079-0570",

publisher = "Springer Nature",

number = "1",

}

RIS

TY - JOUR

T1 - Plasma D-Dimer Level as a Subclinical Marker of Thrombotic Risk in Elderly Patients with Atrial Fibrillation

AU - Zadvorev, S. F.

AU - Zamytskaya, A. A.

AU - Piskunov, D. P.

AU - Pushkin, A. S.

AU - Yakovlev, A. A.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Aged patients with atrial fibrillation (AF) are at high risk of both thromboembolic and hemorrhagic complications of the disease and its treatment. A study was conducted to assess the role of the D-dimer plasma level as a marker of thrombosis in aged patients with AF having no clinical signs of active thrombosis with respect to the used treatment strategy and the quantitative thrombotic and hemorrhagic risk of AF. The results show that the D-dimer plasma levels correlate with the scores of thromboembolic and hemorrhagic risks in groups on antiplatelet agents but not anticoagulants, with the difference in D-dimer level driven by a subgroup on CHA2DS2-VASc point ≥5. A high D-dimer level was associated with in-hospital mortality and AF rhythm at the moment of blood sample collection. Therefore, the accuracy of risk prognosis for fatal complications of AF in elderly patients may be increased with the use of the laboratory markers of thrombus formation such as the D-dimer level and with the use of the obtained results as a guide to antithrombotic therapy.

AB - Aged patients with atrial fibrillation (AF) are at high risk of both thromboembolic and hemorrhagic complications of the disease and its treatment. A study was conducted to assess the role of the D-dimer plasma level as a marker of thrombosis in aged patients with AF having no clinical signs of active thrombosis with respect to the used treatment strategy and the quantitative thrombotic and hemorrhagic risk of AF. The results show that the D-dimer plasma levels correlate with the scores of thromboembolic and hemorrhagic risks in groups on antiplatelet agents but not anticoagulants, with the difference in D-dimer level driven by a subgroup on CHA2DS2-VASc point ≥5. A high D-dimer level was associated with in-hospital mortality and AF rhythm at the moment of blood sample collection. Therefore, the accuracy of risk prognosis for fatal complications of AF in elderly patients may be increased with the use of the laboratory markers of thrombus formation such as the D-dimer level and with the use of the obtained results as a guide to antithrombotic therapy.

KW - anticoagulants

KW - antiplatelet agents

KW - atrial fibrillation

KW - D-dimer

UR - http://www.scopus.com/inward/record.url?scp=85083089924&partnerID=8YFLogxK

U2 - 10.1134/S2079057020010166

DO - 10.1134/S2079057020010166

M3 - Article

C2 - 31512429

VL - 10

SP - 73

EP - 78

JO - Advances in Gerontology

JF - Advances in Gerontology

SN - 2079-0570

IS - 1

ER -

ID: 78611112