TY - JOUR

T1 - Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells

T2 - From Flies to Man

AU - Sinenko, Sergey A.

AU - Starkova, Tatiana Yu

AU - Kuzmin, Andrey A.

AU - Tomilin, Alexey N.

N1 - Publisher Copyright: © Copyright © 2021 Sinenko, Starkova, Kuzmin and Tomilin.

PY - 2021

Y1 - 2021

N2 - Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced NADPH oxidases in the cytosol. In the recent two decades, a plethora of studies established that elevated ROS levels generated by oxidative eustress are crucial physiological mediators of many cellular and developmental processes. In this review, we discuss the mechanisms of ROS generation and regulation, current understanding of ROS functions in the maintenance of adult and embryonic stem cells, as well as in the process of cell reprogramming to a pluripotent state. Recently discovered cell-non-autonomous ROS functions mediated by growth factors are crucial for controlling cell differentiation and cellular immune response in Drosophila. Importantly, many physiological functions of ROS discovered in Drosophila may allow for deciphering and understanding analogous processes in human, which could potentially lead to the development of novel therapeutic approaches in ROS-associated diseases treatment.

AB - Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced NADPH oxidases in the cytosol. In the recent two decades, a plethora of studies established that elevated ROS levels generated by oxidative eustress are crucial physiological mediators of many cellular and developmental processes. In this review, we discuss the mechanisms of ROS generation and regulation, current understanding of ROS functions in the maintenance of adult and embryonic stem cells, as well as in the process of cell reprogramming to a pluripotent state. Recently discovered cell-non-autonomous ROS functions mediated by growth factors are crucial for controlling cell differentiation and cellular immune response in Drosophila. Importantly, many physiological functions of ROS discovered in Drosophila may allow for deciphering and understanding analogous processes in human, which could potentially lead to the development of novel therapeutic approaches in ROS-associated diseases treatment.

KW - drosophila

KW - electron transport chain

KW - embryonic stem cells

KW - hematopoiesis

KW - HMGB1

KW - induced pluripotent stem cells

KW - mitochondria

KW - reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=85113207286&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/b6be337d-0cf8-3a8e-a225-f8c0ca660f3d/

U2 - 10.3389/fcell.2021.714370

DO - 10.3389/fcell.2021.714370

M3 - Review article

C2 - 34422833

AN - SCOPUS:85113207286

VL - 9

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 714370

ER -