TY - JOUR

T1 - Physicochemical Studies on Amino Acid Based Metallosurfactants in Combination with Phospholipid

AU - Barai, Manas

AU - Manna, Emili

AU - Sultana, Habiba

AU - Mandal, Amit Kumar

AU - Manna, Tuhin

AU - Patra, Anuttam

AU - Roy, Biplab

AU - Gowda, Vasantha

AU - Chang, Chien-Hsiang

AU - Акентьев, Александр Владимирович

AU - Быков, Алексей Геннадьевич

AU - Носков, Борис Анатольевич

AU - Moitra, Parkishit

AU - Ghosh, Chandradipa

AU - Yusa, Shin ichi

AU - Bhattacharya, Santanu

AU - Panda, Amiya Kumar

PY - 2024/9/27

Y1 - 2024/9/27

N2 - Dicarboxylate metallosurfactants (AASM), synthesized by mixing N‐dodecyl aminomalonate, ‐aspartate and ‐glutamate with CaCl2, MnCl2 and CdCl2, were characterized by XRD, FTIR, and NMR spectroscopy. Layered structures, formed by metallosurfactants, were evidenced from differential scanning calorimetry and thermogravimetric analyses. Solvent‐spread monolayer of AASM in combination with soyphosphatidylcholine (SPC) and cholesterol (CHOL) were studied using Langmuir surface balance. With increasing mole fraction of AASM mean molecular area increased and passed through maxima at ~60 mol% of AASMs, indicating molecular packing reorganization. Systems with 20 and 60 mol% AASM exhibited positive deviations from ideal behavior signifying repulsive interaction between the AASM and SPC, while synergistic interactions were established from the negative deviation at other combinations. Dynamic surface elasticity increased with increasing surface pressure signifying formation of rigid monolayer. Transition of monolayer from gaseous to liquid expanded to liquid condensed state was established by Brewster angle microscopic studies. Stability of the hybrid vesicles, formed by AASM+SPC+CHOL, was established by monitoring their size, zeta potential and polydispersity index values over 100 days. Size and spherical morphology of hybrid vesicles were confirmed by transmission electron microscopic studies. Biocompatibility of the hybrid vesicles were established by cytotoxicity studies revealing their possible applications in drug delivery and imaging.

AB - Dicarboxylate metallosurfactants (AASM), synthesized by mixing N‐dodecyl aminomalonate, ‐aspartate and ‐glutamate with CaCl2, MnCl2 and CdCl2, were characterized by XRD, FTIR, and NMR spectroscopy. Layered structures, formed by metallosurfactants, were evidenced from differential scanning calorimetry and thermogravimetric analyses. Solvent‐spread monolayer of AASM in combination with soyphosphatidylcholine (SPC) and cholesterol (CHOL) were studied using Langmuir surface balance. With increasing mole fraction of AASM mean molecular area increased and passed through maxima at ~60 mol% of AASMs, indicating molecular packing reorganization. Systems with 20 and 60 mol% AASM exhibited positive deviations from ideal behavior signifying repulsive interaction between the AASM and SPC, while synergistic interactions were established from the negative deviation at other combinations. Dynamic surface elasticity increased with increasing surface pressure signifying formation of rigid monolayer. Transition of monolayer from gaseous to liquid expanded to liquid condensed state was established by Brewster angle microscopic studies. Stability of the hybrid vesicles, formed by AASM+SPC+CHOL, was established by monitoring their size, zeta potential and polydispersity index values over 100 days. Size and spherical morphology of hybrid vesicles were confirmed by transmission electron microscopic studies. Biocompatibility of the hybrid vesicles were established by cytotoxicity studies revealing their possible applications in drug delivery and imaging.

UR - https://www.mendeley.com/catalogue/fd01b732-1c37-3fb4-9b81-edb1c4eb2145/

U2 - 10.1002/asia.202400284

DO - 10.1002/asia.202400284

M3 - Article

VL - 19

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

SN - 1861-4728

IS - 20

M1 - e202400284

ER -