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Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages. / Krutetskaya, Z.I.; Milenina, L.S.; Naumova, A.A.; Antonov, V.G.; Nozdrachev, A.D.

в: Doklady Biochemistry and Biophysics, Том 465, № 1, 2015, стр. 374 - 376.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Krutetskaya, ZI, Milenina, LS, Naumova, AA, Antonov, VG & Nozdrachev, AD 2015, 'Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages', Doklady Biochemistry and Biophysics, Том. 465, № 1, стр. 374 - 376. https://doi.org/10.1134/S1607672915060083, https://doi.org/10.1134/S1607672915060083

APA

Krutetskaya, Z. I., Milenina, L. S., Naumova, A. A., Antonov, V. G., & Nozdrachev, A. D. (2015). Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages. Doklady Biochemistry and Biophysics, 465(1), 374 - 376. https://doi.org/10.1134/S1607672915060083, https://doi.org/10.1134/S1607672915060083

Vancouver

Krutetskaya ZI, Milenina LS, Naumova AA, Antonov VG, Nozdrachev AD. Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages. Doklady Biochemistry and Biophysics. 2015;465(1):374 - 376. https://doi.org/10.1134/S1607672915060083, https://doi.org/10.1134/S1607672915060083

Author

Krutetskaya, Z.I. ; Milenina, L.S. ; Naumova, A.A. ; Antonov, V.G. ; Nozdrachev, A.D. / Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages. в: Doklady Biochemistry and Biophysics. 2015 ; Том 465, № 1. стр. 374 - 376.

BibTeX

@article{631595bd371d4b0d89a8e6114f65f84c,
title = "Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages",
abstract = "{\textcopyright} 2015, Pleiades Publishing, Ltd.Using the fluorescent Ca2+ probe Fura-2AM, the possible involvement of phospholipase A2, the key enzyme in the arachidonic acid cascade, in the effect of drugs glutoxim and molixan on the intracellular Ca2+ concentration in macrophages was studied. It was shown for the first time that preincubation of macrophages with the classical phospholipase A2 inhibitor, 4-bromophenacyl bromide, as well as with glucocorticosteroids prednisolone and dexamethasone significantly inhibits Ca2+ responses induced by glutoxim or molixan in macrophages. These results indicate the involvement of phospholipase A2 and arachidonic acid cascade in glutoximand molixan-induced signaling in macrophages.",
author = "Z.I. Krutetskaya and L.S. Milenina and A.A. Naumova and V.G. Antonov and A.D. Nozdrachev",
note = "Krutetskaya Z. I., Milenina L. S., Naumova A. A., Antonov V. G., Nozdrachev A. D. Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages // Doklady Biochemistry and Biophysics, 2015. — Vol. 465, — № 374-376.",
year = "2015",
doi = "10.1134/S1607672915060083",
language = "English",
volume = "465",
pages = "374 -- 376",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "1",

}

RIS

TY - JOUR

T1 - Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages

AU - Krutetskaya, Z.I.

AU - Milenina, L.S.

AU - Naumova, A.A.

AU - Antonov, V.G.

AU - Nozdrachev, A.D.

N1 - Krutetskaya Z. I., Milenina L. S., Naumova A. A., Antonov V. G., Nozdrachev A. D. Phospholipase A2 inhibitors modulate the effects of glutoxim and molixan on the intracellular Ca2+ level in macrophages // Doklady Biochemistry and Biophysics, 2015. — Vol. 465, — № 374-376.

PY - 2015

Y1 - 2015

N2 - © 2015, Pleiades Publishing, Ltd.Using the fluorescent Ca2+ probe Fura-2AM, the possible involvement of phospholipase A2, the key enzyme in the arachidonic acid cascade, in the effect of drugs glutoxim and molixan on the intracellular Ca2+ concentration in macrophages was studied. It was shown for the first time that preincubation of macrophages with the classical phospholipase A2 inhibitor, 4-bromophenacyl bromide, as well as with glucocorticosteroids prednisolone and dexamethasone significantly inhibits Ca2+ responses induced by glutoxim or molixan in macrophages. These results indicate the involvement of phospholipase A2 and arachidonic acid cascade in glutoximand molixan-induced signaling in macrophages.

AB - © 2015, Pleiades Publishing, Ltd.Using the fluorescent Ca2+ probe Fura-2AM, the possible involvement of phospholipase A2, the key enzyme in the arachidonic acid cascade, in the effect of drugs glutoxim and molixan on the intracellular Ca2+ concentration in macrophages was studied. It was shown for the first time that preincubation of macrophages with the classical phospholipase A2 inhibitor, 4-bromophenacyl bromide, as well as with glucocorticosteroids prednisolone and dexamethasone significantly inhibits Ca2+ responses induced by glutoxim or molixan in macrophages. These results indicate the involvement of phospholipase A2 and arachidonic acid cascade in glutoximand molixan-induced signaling in macrophages.

U2 - 10.1134/S1607672915060083

DO - 10.1134/S1607672915060083

M3 - Article

VL - 465

SP - 374

EP - 376

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 3975091