TY - JOUR

T1 - Pharmacological characterization of a novel putative nootropic beta-alanine derivative, MB-005, in adult zebrafish

AU - Kolesnikova, Tatiana O

AU - Galstyan, David S

AU - Demin, Konstantin A

AU - Barabanov, Mikhail A

AU - Pestov, Alexander V

AU - S de Abreu, Murilo

AU - Strekalova, Tatyana

AU - Kalueff, Allan V

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/7

Y1 - 2022/7

N2 - BACKGROUND: Cognitive deficits represent an urgent biomedical problem, and are commonly reduced by nootropic drugs. Animal models, including both rodents and zebrafish, offer a valuable tool for studying cognitive phenotypes and screening novel nootropics. Beta-alanine and its derivatives have recently been proposed to exert nootropic activity.AIMS: This study aimed to characterize putative nootropic profile of a novel β-alanine analogue, 1,3-diaminopropane (MB-005), in adult zebrafish.METHODS: Nootropic profile of MB-005 was assessed in adult zebrafish in the novel tank and conditioned place aversion (CPA) tests acutely, and in cued-learning plus-maze (PMT) tests chronically.RESULTS/OUTCOMES: MB-005 did not alter zebrafish anxiety-like behavior or monoamine neurochemistry acutely, improved short-term memory in the CPA test, but impaired cognitive performance in both CPA and PMT tests chronically.CONCLUSIONS/INTERPRETATION: This study reveals high sensitivity of zebrafish cognitive phenotypes to MB-005, suggesting it as a potential novel cognitive enhancer acutely, but raises concerns over its cognitive (and, possibly, other) side-effects chronically.

AB - BACKGROUND: Cognitive deficits represent an urgent biomedical problem, and are commonly reduced by nootropic drugs. Animal models, including both rodents and zebrafish, offer a valuable tool for studying cognitive phenotypes and screening novel nootropics. Beta-alanine and its derivatives have recently been proposed to exert nootropic activity.AIMS: This study aimed to characterize putative nootropic profile of a novel β-alanine analogue, 1,3-diaminopropane (MB-005), in adult zebrafish.METHODS: Nootropic profile of MB-005 was assessed in adult zebrafish in the novel tank and conditioned place aversion (CPA) tests acutely, and in cued-learning plus-maze (PMT) tests chronically.RESULTS/OUTCOMES: MB-005 did not alter zebrafish anxiety-like behavior or monoamine neurochemistry acutely, improved short-term memory in the CPA test, but impaired cognitive performance in both CPA and PMT tests chronically.CONCLUSIONS/INTERPRETATION: This study reveals high sensitivity of zebrafish cognitive phenotypes to MB-005, suggesting it as a potential novel cognitive enhancer acutely, but raises concerns over its cognitive (and, possibly, other) side-effects chronically.

KW - Nootropics

KW - memory

KW - piracetam

KW - zebrafish

KW - β-alanine

KW - Behavior, Animal

KW - Cues

KW - beta-Alanine/pharmacology

KW - Animals

KW - Nootropic Agents/pharmacology

KW - Zebrafish

KW - Anxiety

UR - http://www.scopus.com/inward/record.url?scp=85132416523&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2ee94f96-34f6-371d-b70c-8dc919ad91a5/

U2 - 10.1177/02698811221098192

DO - 10.1177/02698811221098192

M3 - Article

C2 - 35713386

VL - 36

SP - 892

EP - 902

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 7

ER -